About   Help   FAQ
Gene Expression Literature Summary
Assay
Age
Immunohistochemistry (section)
12.5 DPC

354 matching records from 354 references.

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Casp3  caspase 3   (Synonyms: A830040C14Rik, AC-3, Apopain, Caspase-3, CC3, CPP32, mldy, Yama)
Results  Reference
1J:103452 Abbott MA, Joksimovic M, Tuggle CK, Ectopic HOXA5 expression results in abnormal differentiation, migration and p53-independent cell death of superficial dorsal horn neurons. Brain Res Dev Brain Res. 2005 Oct 6;159(2):87-97
1J:278544 Abdelhamed ZA, Abdelmottaleb DI, El-Asrag ME, Natarajan S, Wheway G, Inglehearn CF, Toomes C, Johnson CA, The ciliary Frizzled-like receptor Tmem67 regulates canonical Wnt/beta-catenin signalling in the developing cerebellum via Hoxb5. Sci Rep. 2019 Apr 1;9(1):5446
1*J:274050 Abramowski V, Etienne O, Elsaid R, Yang J, Berland A, Kermasson L, Roch B, Musilli S, Moussu JP, Lipson-Ruffert K, Revy P, Cumano A, Boussin FD, de Villartay JP, PAXX and Xlf interplay revealed by impaired CNS development and immunodeficiency of double KO mice. Cell Death Differ. 2018 Feb;25(2):444-452
1*J:120961 Adam J, Deans B, Thacker J, A role for Xrcc2 in the early stages of mouse development. DNA Repair (Amst). 2007 Feb 4;6(2):224-34
1J:245045 Aghajanian H, Cho YK, Rizer NW, Wang Q, Li L, Degenhardt K, Jain R, Pdgfralpha functions in endothelial-derived cells to regulate neural crest cells and the development of the great arteries. Dis Model Mech. 2017 Sep 01;10(9):1101-1108
1J:284118 Ahmed M, Marziali LN, Arenas E, Feltri ML, Ffrench-Constant C, Laminin alpha2 controls mouse and human stem cell behaviour during midbrain dopaminergic neuron development. Development. 2019 Aug 29;146(16):dev172668
1J:194074 Ahn Y, Sims C, Logue JM, Weatherbee SD, Krumlauf R, Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling. Development. 2013 Feb 1;140(3):583-93
1*J:211339 Al-Zahrani KN, Sekhon P, Tessier DR, Yockell-Lelievre J, Pryce BR, Baron KD, Howe GA, Sriram RK, Daniel K, Mckay M, Lo V, Quizi J, Addison CL, Gruslin A, Sabourin LA, Essential role for the SLK protein kinase in embryogenesis and placental tissue development. Dev Dyn. 2014 May;243(5):640-51
1*J:271028 Albers E, Sbroggio M, Pladevall-Morera D, Bizard AH, Avram A, Gonzalez P, Martin-Gonzalez J, Hickson ID, Lopez-Contreras AJ, Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality. Cell Rep. 2018 Sep 18;24(12):3274-3284
1J:267338 Angelim MKSC, Maia LMSS, Mouffle C, Ginhoux F, Low D, Amancio-Dos-Santos A, Makhoul J, Le Corronc H, Mangin JM, Legendre P, Embryonic macrophages and microglia ablation alter the development of dorsal root ganglion sensory neurons in mouse embryos. Glia. 2018 Nov;66(11):2470-2486
1J:137346 Arbour N, Vanderluit JL, Le Grand JN, Jahani-Asl A, Ruzhynsky VA, Cheung EC, Kelly MA, MacKenzie AE, Park DS, Opferman JT, Slack RS, Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage. J Neurosci. 2008 Jun 11;28(24):6068-78
1J:288305 Aslanpour S, Rosin JM, Balakrishnan A, Klenin N, Blot F, Gradwohl G, Schuurmans C, Kurrasch DM, Ascl1 is required to specify a subset of ventromedial hypothalamic neurons. Development. 2020 May 28;147(10):dev180067
1J:149014 Bakker ML, Boukens BJ, Mommersteeg MT, Brons JF, Wakker V, Moorman AF, Christoffels VM, Transcription factor Tbx3 is required for the specification of the atrioventricular conduction system. Circ Res. 2008 Jun 6;102(11):1340-9
1J:334460 Bando H, Brinkmeier ML, Castinetti F, Fang Q, Lee MS, Saveanu A, Albarel F, Dupuis C, Brue T, Camper SA, Heterozygous variants in SIX3 and POU1F1 cause pituitary hormone deficiency in mouse and man. Hum Mol Genet. 2023 Jan 13;32(3):367-385
1J:171088 Barnes RM, Firulli BA, Vandusen NJ, Morikawa Y, Conway SJ, Cserjesi P, Vincentz JW, Firulli AB, Hand2 Loss-of-Function in Hand1-Expressing Cells Reveals Distinct Roles in Epicardial and Coronary Vessel Development. Circ Res. 2011 Apr 15;108(8):940-9
1J:288459 Bartesaghi L, Wang Y, Fontanet P, Wanderoy S, Berger F, Wu H, Akkuratova N, Boucanova F, Medard JJ, Petitpre C, Landy MA, Zhang MD, Harrer P, Stendel C, Stucka R, Dusl M, Kastriti ME, Croci L, Lai HC, Consalez GG, Pattyn A, Ernfors P, Senderek J, Adameyko I, Lallemend F, Hadjab S, Chrast R, PRDM12 Is Required for Initiation of the Nociceptive Neuron Lineage during Neurogenesis. Cell Rep. 2019 Mar 26;26(13):3484-3492.e4
1*J:266583 Baumgartner M, Olthof AM, Aquino GS, Hyatt KC, Lemoine C, Drake K, Sturrock N, Nguyen N, Al Seesi S, Kanadia RN, Minor spliceosome inactivation causes microcephaly, owing to cell cycle defects and death of self-amplifying radial glial cells. Development. 2018 Aug 28;145(17):dev166322
1J:157997 Beck L, Leroy C, Beck-Cormier S, Forand A, Salaun C, Paris N, Bernier A, Urena-Torres P, Prie D, Ollero M, Coulombel L, Friedlander G, The phosphate transporter PiT1 (Slc20a1) revealed as a new essential gene for mouse liver development. PLoS One. 2010;5(2):e9148
1J:211278 Belzil C, Asada N, Ishiguro K, Nakaya T, Parsons K, Pendolino V, Neumayer G, Mapelli M, Nakatani Y, Sanada K, Nguyen MD, p600 regulates spindle orientation in apical neural progenitors and contributes to neurogenesis in the developing neocortex. Biol Open. 2014;3(6):475-85
1J:142362 Ben-Zvi A, Manor O, Schachner M, Yaron A, Tessier-Lavigne M, Behar O, The Semaphorin receptor PlexinA3 mediates neuronal apoptosis during dorsal root ganglia development. J Neurosci. 2008 Nov 19;28(47):12427-32
1J:284524 Bendriem RM, Singh S, Aleem AA, Antonetti DA, Ross ME, Tight junction protein occludin regulates progenitor Self-Renewal and survival in developing cortex. Elife. 2019 Dec 3;8:e49376
1J:227232 Bin JM, Han D, Lai Wing Sun K, Croteau LP, Dumontier E, Cloutier JF, Kania A, Kennedy TE, Complete Loss of Netrin-1 Results in Embryonic Lethality and Severe Axon Guidance Defects without Increased Neural Cell Death. Cell Rep. 2015 Aug 18;12(7):1099-106
1J:339096 Biswas S, Chan CS, Rubenstein JLR, Gan L, The transcription regulator Lmo3 is required for the development of medial ganglionic eminence derived neurons in the external globus pallidus. Dev Biol. 2023 Aug 1;503:10-24
1J:319558 Bizen N, Bepari AK, Zhou L, Abe M, Sakimura K, Ono K, Takebayashi H, Ddx20, an Olig2 binding factor, governs the survival of neural and oligodendrocyte progenitor cells via proper Mdm2 splicing and p53 suppression. Cell Death Differ. 2022;
1J:239777 Boucherat O, Landry-Truchon K, Berube-Simard FA, Houde N, Beuret L, Lezmi G, Foulkes WD, Delacourt C, Charron J, Jeannotte L, Epithelial inactivation of Yy1 abrogates lung branching morphogenesis. Development. 2015 Sep 01;142(17):2981-95
1J:214083 Boucherat O, Nadeau V, Berube-Simard FA, Charron J, Jeannotte L, Crucial requirement of ERK/MAPK signaling in respiratory tract development. Development. 2014 Aug;141(16):3197-211
1J:279716 Braitsch CM, Azizoglu DB, Htike Y, Barlow HR, Schnell U, Chaney CP, Carroll TJ, Stanger BZ, Cleaver O, LATS1/2 suppress NFkappaB and aberrant EMT initiation to permit pancreatic progenitor differentiation. PLoS Biol. 2019 Jul;17(7):e3000382
1J:175160 Braunstein EM, Crenshaw EB 3rd, Morrow BE, Adams JC, Cooperative function of Tbx1 and Brn4 in the periotic mesenchyme is necessary for cochlea formation. J Assoc Res Otolaryngol. 2008 Mar;9(1):33-43
1J:154462 Breuskin I, Bodson M, Thelen N, Thiry M, Borgs L, Nguyen L, Lefebvre PP, Malgrange B, Sox10 promotes the survival of cochlear progenitors during the establishment of the organ of Corti. Dev Biol. 2009 Nov 15;335(2):327-39
1*J:286303 Buckley DM, Burroughs-Garcia J, Kriks S, Lewandoski M, Waters ST, Gbx1 and Gbx2 Are Essential for Normal Patterning and Development of Interneurons and Motor Neurons in the Embryonic Spinal Cord. J Dev Biol. 2020 Apr 1;8(2)
1J:112971 Camarero G, Tyrsin OY, Xiang C, Pfeiffer V, Pleiser S, Wiese S, Gotz R, Rapp UR, Cortical migration defects in mice expressing A-RAF from the B-RAF locus. Mol Cell Biol. 2006 Oct;26(19):7103-15
1*J:139570 Capellini TD, Zewdu R, Di Giacomo G, Asciutti S, Kugler JE, Di Gregorio A, Selleri L, Pbx1/Pbx2 govern axial skeletal development by controlling Polycomb and Hox in mesoderm and Pax1/Pax9 in sclerotome. Dev Biol. 2008 Sep 15;321(2):500-14
1J:264379 Cardenas A, Villalba A, de Juan Romero C, Pico E, Kyrousi C, Tzika AC, Tessier-Lavigne M, Ma L, Drukker M, Cappello S, Borrell V, Evolution of Cortical Neurogenesis in Amniotes Controlled by Robo Signaling Levels. Cell. 2018 Jul 26;174(3):590-606.e21
1J:175836 Cariboni A, Davidson K, Dozio E, Memi F, Schwarz Q, Stossi F, Parnavelas JG, Ruhrberg C, VEGF signalling controls GnRH neuron survival via NRP1 independently of KDR and blood vessels. Development. 2011 Sep;138(17):3723-33
1J:272505 Catela C, Correa E, Wen K, Aburas J, Croci L, Consalez GG, Kratsios P, An ancient role for collier/Olf/Ebf (COE)-type transcription factors in axial motor neuron development. Neural Dev. 2019 Jan 18;14(1):2
1J:339840 Causeret F, Fayon M, Moreau MX, Ne E, Oleari R, Parras C, Cariboni A, Pierani A, Diversity within olfactory sensory derivatives revealed by the contribution of Dbx1 lineages. J Comp Neurol. 2023 Aug;531(12):1229-1243
1J:49840 Cecconi F, Alvarez-Bolado G, Meyer BI, Roth KA, Gruss P, Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. Cell. 1998 Sep 18;94(6):727-37
1*J:267540 Cesario JM, Landin Malt A, Chung JU, Khairallah MP, Dasgupta K, Asam K, Deacon LJ, Choi V, Almaidhan AA, Darwiche NA, Kim J, Johnson RL, Jeong J, Anti-osteogenic function of a LIM-homeodomain transcription factor LMX1B is essential to early patterning of the calvaria. Dev Biol. 2018 Nov 15;443(2):103-116
1J:300487 Chai G, Webb A, Li C, Antaki D, Lee S, Breuss MW, Lang N, Stanley V, Anzenberg P, Yang X, Marshall T, Gaffney P, Wierenga KJ, Chung BH, Tsang MH, Pais LS, Lovgren AK, VanNoy GE, Rehm HL, Mirzaa G, Leon E, Diaz J, Neumann A, Kalverda AP, Manfield IW, Parry DA, Logan CV, Johnson CA, Bonthron DT, Valleley EMA, Issa MY, Abdel-Ghafar SF, Abdel-Hamid MS, Jennings P, Zaki MS, Sheridan E, Gleeson JG, Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly. Neuron. 2021 Jan 20;109(2):241-256.e9
1J:241997 Chatzeli L, Gaete M, Tucker AS, Fgf10 and Sox9 are essential for the establishment of distal progenitor cells during mouse salivary gland development. Development. 2017 Jun 15;144(12):2294-2305
1J:225805 Chen C, Lee GA, Pourmorady A, Sock E, Donoghue MJ, Orchestration of Neuronal Differentiation and Progenitor Pool Expansion in the Developing Cortex by SoxC Genes. J Neurosci. 2015 Jul 22;35(29):10629-42
1J:153554 Chen J, Lan Y, Baek JA, Gao Y, Jiang R, Wnt/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth development. Dev Biol. 2009 Oct 1;334(1):174-85
1J:166699 Chen L, Chatterjee M, Li JY, The mouse homeobox gene Gbx2 is required for the development of cholinergic interneurons in the striatum. J Neurosci. 2010 Nov 3;30(44):14824-34
1J:339854 Chen SY, Liu FC, The Fgf9-Nolz1-Wnt2 axis regulates morphogenesis of the lung. Development. 2023 Aug 15;150(16):dev201827
1J:268047 Cheng I, Jin L, Rose LC, Deppmann CD, Temporally restricted death and the role of p75NTR as a survival receptor in the developing sensory nervous system. Dev Neurobiol. 2018 Jul;78(7):701-717
1J:213171 Cheng L, Desai J, Miranda CJ, Duncan JS, Qiu W, Nugent AA, Kolpak AL, Wu CC, Drokhlyansky E, Delisle MM, Chan WM, Wei Y, Propst F, Reck-Peterson SL, Fritzsch B, Engle EC, Human CFEOM1 mutations attenuate KIF21A autoinhibition and cause oculomotor axon stalling. Neuron. 2014 Apr 16;82(2):334-49
1J:273599 Cheng S, Liu T, Hu Y, Xia Y, Hou J, Huang C, Zou X, Liang J, Stone Shi Y, Zheng Y, Lu J, Chen G, Conditional Inactivation of Pen-2 in the Developing Neocortex Leads to Rapid Switch of Apical Progenitors to Basal Progenitors. J Neurosci. 2019 Mar 20;39(12):2195-2207
1J:133461 Choi PS, Zakhary L, Choi WY, Caron S, Alvarez-Saavedra E, Miska EA, McManus M, Harfe B, Giraldez AJ, Horvitz RH, Schier AF, Dulac C, Members of the miRNA-200 family regulate olfactory neurogenesis. Neuron. 2008 Jan 10;57(1):41-55
1J:238975 Clovis YM, Seo SY, Kwon JS, Rhee JC, Yeo S, Lee JW, Lee S, Lee SK, Chx10 Consolidates V2a Interneuron Identity through Two Distinct Gene Repression Modes. Cell Rep. 2016 Aug 09;16(6):1642-52
1J:228101 Comai G, Sambasivan R, Gopalakrishnan S, Tajbakhsh S, Variations in the efficiency of lineage marking and ablation confound distinctions between myogenic cell populations. Dev Cell. 2014 Dec 8;31(5):654-67
1*J:271138 Coulter ME, Dorobantu CM, Lodewijk GA, Delalande F, Cianferani S, Ganesh VS, Smith RS, Lim ET, Xu CS, Pang S, Wong ET, Lidov HGW, Calicchio ML, Yang E, Gonzalez DM, Schlaeger TM, Mochida GH, Hess H, Lee WA, Lehtinen MK, Kirchhausen T, Haussler D, Jacobs FMJ, Gaudin R, Walsh CA, The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles. Cell Rep. 2018 Jul 24;24(4):973-986.e8
1J:195725 D'Angelo A, De Angelis A, Avallone B, Piscopo I, Tammaro R, Studer M, Franco B, Ofd1 controls dorso-ventral patterning and axoneme elongation during embryonic brain development. PLoS One. 2012;7(12):e52937
1J:312371 Da Silva F, Zhang K, Pinson A, Fatti E, Wilsch-Brauninger M, Herbst J, Vidal V, Schedl A, Huttner WB, Niehrs C, Mitotic WNT signalling orchestrates neurogenesis in the developing neocortex. EMBO J. 2021 Oct 1;40(19):e108041
1J:304767 Dash S, Bhatt S, Falcon KT, Sandell LL, Trainor PA, Med23 Regulates Sox9 Expression during Craniofacial Development. J Dent Res. 2021 Apr;100(4):406-414
1J:317403 De Clercq S, Gembarska A, Denecker G, Maetens M, Naessens M, Haigh K, Haigh JJ, Marine JC, Widespread overexpression of epitope-tagged Mdm4 does not accelerate tumor formation in vivo. Mol Cell Biol. 2010 Nov;30(22):5394-405
1J:237345 Dee A, Li K, Heng X, Guo Q, Li JY, Regulation of self-renewing neural progenitors by FGF/ERK signaling controls formation of the inferior colliculus. Development. 2016 Oct 15;143(20):3661-3673
1J:211622 DeFalco T, Bhattacharya I, Williams AV, Sams DM, Capel B, Yolk-sac-derived macrophages regulate fetal testis vascularization and morphogenesis. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):E2384-93
1J:271411 Deliu E, Arecco N, Morandell J, Dotter CP, Contreras X, Girardot C, Kasper EL, Kozlova A, Kishi K, Chiaradia I, Noh KM, Novarino G, Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental gene expression and cognition. Nat Neurosci. 2018 Dec;21(12):1717-1727
1J:188332 Delogu A, Sellers K, Zagoraiou L, Bocianowska-Zbrog A, Mandal S, Guimera J, Rubenstein JL, Sugden D, Jessell T, Lumsden A, Subcortical visual shell nuclei targeted by ipRGCs develop from a Sox14+-GABAergic progenitor and require Sox14 to regulate daily activity rhythms. Neuron. 2012 Aug 23;75(4):648-62
1J:244825 Dennis DJ, Wilkinson G, Li S, Dixit R, Adnani L, Balakrishnan A, Han S, Kovach C, Gruenig N, Kurrasch DM, Dyck RH, Schuurmans C, Neurog2 and Ascl1 together regulate a postmitotic derepression circuit to govern laminar fate specification in the murine neocortex. Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):E4934-E4943
1J:99355 Depaepe V, Suarez-Gonzalez N, Dufour A, Passante L, Gorski JA, Jones KR, Ledent C, Vanderhaeghen P, Ephrin signalling controls brain size by regulating apoptosis of neural progenitors. Nature. 2005 Jun 30;435(7046):1244-50
1J:283226 Desiderio S, Vermeiren S, Van Campenhout C, Kricha S, Malki E, Richts S, Fletcher EV, Vanwelden T, Schmidt BZ, Henningfeld KA, Pieler T, Woods CG, Nagy V, Verfaillie C, Bellefroid EJ, Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA. Cell Rep. 2019 Mar 26;26(13):3522-3536.e5
1J:301004 Di Marco B, Crouch EE, Shah B, Duman C, Paredes MF, Ruiz de Almodovar C, Huang EJ, Alfonso J, Reciprocal Interaction between Vascular Filopodia and Neural Stem Cells Shapes Neurogenesis in the Ventral Telencephalon. Cell Rep. 2020 Oct 13;33(2):108256
1J:332091 Ding W, Zhang C, Wang B, Zhou X, Sun L, Zhong S, Liu J, Zhang J, Wang X, Wu Q, Loss of the centrosomal protein Cenpj leads to dysfunction of the hypothalamus and obesity in mice. Sci China Life Sci. 2021 Mar;64(3):419-433
1J:205579 Dixit R, Wilkinson G, Cancino GI, Shaker T, Adnani L, Li S, Dennis D, Kurrasch D, Chan JA, Olson EC, Kaplan DR, Zimmer C, Schuurmans C, Neurog1 and Neurog2 control two waves of neuronal differentiation in the piriform cortex. J Neurosci. 2014 Jan 8;34(2):539-53
1J:221324 Dorr KM, Amin NM, Kuchenbrod LM, Labiner H, Charpentier MS, Pevny LH, Wessels A, Conlon FL, Casz1 is required for cardiomyocyte G1-to-S phase progression during mammalian cardiac development. Development. 2015 Jun 1;142(11):2037-47
1J:213791 Dutta DJ, Zameer A, Mariani JN, Zhang J, Asp L, Huynh J, Mahase S, Laitman BM, Argaw AT, Mitiku N, Urbanski M, Melendez-Vasquez CV, Casaccia P, Hayot F, Bottinger EP, Brown CW, John GR, Combinatorial actions of Tgfbeta and Activin ligands promote oligodendrocyte development and CNS myelination. Development. 2014 Jun;141(12):2414-28
1J:174726 Eckler MJ, McKenna WL, Taghvaei S, McConnell SK, Chen B, Fezf1 and Fezf2 are required for olfactory development and sensory neuron identity. J Comp Neurol. 2011 Jul 1;519(10):1829-46
1J:206141 Eguren M, Porlan E, Manchado E, Garcia-Higuera I, Canamero M, Farinas I, Malumbres M, The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors. Nat Commun. 2013;4:2880
1*J:130185 Ellsworth BS, Butts DL, Camper SA, Mechanisms underlying pituitary hypoplasia and failed cell specification in Lhx3-deficient mice. Dev Biol. 2008 Jan 1;313(1):118-29
1J:186284 Espana A, Clotman F, Onecut transcription factors are required for the second phase of development of the A13 dopaminergic nucleus in the mouse. J Comp Neurol. 2012 May 1;520(7):1424-41
1J:196818 Espana A, Clotman F, Onecut factors control development of the Locus Coeruleus and of the mesencephalic trigeminal nucleus. Mol Cell Neurosci. 2012 May;50(1):93-102
1J:285759 Esteve P, Crespo I, Kaimakis P, Sandonis A, Bovolenta P, Sfrp1 Modulates Cell-signaling Events Underlying Telencephalic Patterning, Growth and Differentiation. Cereb Cortex. 2019 Mar 1;29(3):1059-1074
1J:267941 Fakhouri WD, Metwalli K, Naji A, Bakhiet S, Quispe-Salcedo A, Nitschke L, Kousa YA, Schutte BC, Intercellular Genetic Interaction Between Irf6 and Twist1 during Craniofacial Development. Sci Rep. 2017 Aug 2;7(1):7129
1J:168595 Feng L, Xie ZH, Ding Q, Xie X, Libby RT, Gan L, MATH5 controls the acquisition of multiple retinal cell fates. Mol Brain. 2010;3:36
1J:305200 Fernandez V, Martinez-Martinez MA, Prieto-Colomina A, Cardenas A, Soler R, Dori M, Tomasello U, Nomura Y, Lopez-Atalaya JP, Calegari F, Borrell V, Repression of Irs2 by let-7 miRNAs is essential for homeostasis of the telencephalic neuroepithelium. EMBO J. 2020 Nov 2;39(21):e105479
1J:340498 Fernandez-Santos B, Reyes-Corral M, Caro-Vega JM, Lao-Perez M, Vallejo-Grijalba C, Mesa-Cruz C, Moron FJ, Ybot-Gonzalez P, The loop-tail mouse model displays open and closed caudal neural tube defects. Dis Model Mech. 2023 Aug 1;16(8)
1*J:198483 Finelli MJ, Murphy KJ, Chen L, Zou H, Differential phosphorylation of Smad1 integrates BMP and neurotrophin pathways through Erk/Dusp in axon development. Cell Rep. 2013 May 30;3(5):1592-606
1J:170384 Fischer T, Faus-Kessler T, Welzl G, Simeone A, Wurst W, Prakash N, Fgf15-mediated control of neurogenic and proneural gene expression regulates dorsal midbrain neurogenesis. Dev Biol. 2011 Feb 15;350(2):496-510
1J:306166 Flasse L, Yennek S, Cortijo C, Barandiaran IS, Kraus MR, Grapin-Botton A, Apical Restriction of the Planar Cell Polarity Component VANGL in Pancreatic Ducts Is Required to Maintain Epithelial Integrity. Cell Rep. 2020 May 26;31(8):107677
1*J:93609 Fuccillo M, Rallu M, McMahon AP, Fishell G, Temporal requirement for hedgehog signaling in ventral telencephalic patterning. Development. 2004 Oct;131(20):5031-40
1J:166947 Fujimori S, Novak H, Weissenbock M, Jussila M, Goncalves A, Zeller R, Galloway J, Thesleff I, Hartmann C, Wnt/beta-catenin signaling in the dental mesenchyme regulates incisor development by regulating Bmp4. Dev Biol. 2010 Dec 1;348(1):97-106
1J:316577 Furlan A, Lamballe F, Stagni V, Hussain A, Richelme S, Prodosmo A, Moumen A, Brun C, Del Barco Barrantes I, Arthur JS, Koleske AJ, Nebreda AR, Barila D, Maina F, Met acts through Abl to regulate p53 transcriptional outcomes and cell survival in the developing liver. J Hepatol. 2012 Dec;57(6):1292-8
1J:189010 Gaengel K, Niaudet C, Hagikura K, Siemsen BL, Muhl L, Hofmann JJ, Ebarasi L, Nystrom S, Rymo S, Chen LL, Pang MF, Jin Y, Raschperger E, Roswall P, Schulte D, Benedito R, Larsson J, Hellstrom M, Fuxe J, Uhlen P, Adams R, Jakobsson L, Majumdar A, VestweberD, Uv A, Betsholtz C, The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2. Dev Cell. 2012 Sep 11;23(3):587-99
1J:114498 Gan B, Peng X, Nagy T, Alcaraz A, Gu H, Guan JL, Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways. J Cell Biol. 2006 Oct 9;175(1):121-33
1J:335821 Gao G, Li X, Jiang Z, Osorio L, Tang YL, Yu X, Jin G, Zhou Z, Isthmin-1 (Ism1) modulates renal branching morphogenesis and mesenchyme condensation during early kidney development. Nat Commun. 2023 Apr 25;14(1):2378
1J:164668 Gascon E, Gaillard S, Malapert P, Liu Y, Rodat-Despoix L, Samokhvalov IM, Delmas P, Helmbacher F, Maina F, Moqrich A, Hepatocyte growth factor-Met signaling is required for Runx1 extinction and peptidergic differentiation in primary nociceptive neurons. J Neurosci. 2010 Sep 15;30(37):12414-23
1J:266784 Gay MH, Valenta T, Herr P, Paratore-Hari L, Basler K, Sommer L, Distinct adhesion-independent functions of beta-catenin control stage-specific sensory neurogenesis and proliferation. BMC Biol. 2015 Apr 11;13:24
1J:266250 Geng A, Qiu R, Murai K, Liu J, Wu X, Zhang H, Farhoodi H, Duong N, Jiang M, Yee JK, Tsark W, Lu Q, KIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development. Nat Commun. 2018 Jul 13;9(1):2707
1*J:119274 Georgia S, Soliz R, Li M, Zhang P, Bhushan A, p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors. Dev Biol. 2006 Oct 1;298(1):22-31
1*J:181048 Ghosh AP, Cape JD, Klocke BJ, Roth KA, Deficiency of pro-apoptotic Hrk attenuates programmed cell death in the developing murine nervous system but does not affect Bcl-x deficiency-induced neuron apoptosis. J Histochem Cytochem. 2011 Nov;59(11):976-83
1*J:82456 Gianino S, Grider JR, Cresswell J, Enomoto H, Heuckeroth RO, GDNF availability determines enteric neuron number by controlling precursor proliferation. Development. 2003 May;130(10):2187-98
1J:286645 Gilet JG, Ivanova EL, Trofimova D, Rudolf G, Meziane H, Broix L, Drouot N, Courraud J, Skory V, Voulleminot P, Osipenko M, Bahi-Buisson N, Yalcin B, Birling MC, Hinckelmann MV, Kwok BH, Allingham JS, Chelly J, Conditional switching of KIF2A mutation provides new insights into cortical malformation pathogeny. Hum Mol Genet. 2020 Mar 27;29(5):766-784
1J:104420 Glasgow SM, Henke RM, Macdonald RJ, Wright CV, Johnson JE, Ptf1a determines GABAergic over glutamatergic neuronal cell fate in the spinal cord dorsal horn. Development. 2005 Dec;132(24):5461-9
1J:151321 Glickstein SB, Monaghan JA, Koeller HB, Jones TK, Ross ME, Cyclin D2 is critical for intermediate progenitor cell proliferation in the embryonic cortex. J Neurosci. 2009 Jul 29;29(30):9614-24
1J:127074 Glickstein SB, Moore H, Slowinska B, Racchumi J, Suh M, Chuhma N, Ross ME, Selective cortical interneuron and GABA deficits in cyclin D2-null mice. Development. 2007 Nov;134(22):4083-93
1J:290788 Gnedeva K, Wang X, McGovern MM, Barton M, Tao L, Trecek T, Monroe TO, Llamas J, Makmura W, Martin JF, Groves AK, Warchol M, Segil N, Organ of Corti size is governed by Yap/Tead-mediated progenitor self-renewal. Proc Natl Acad Sci U S A. 2020 Jun 16;117(24):13552-13561
1J:280117 Gong X, Guo X, Huang R, Liao H, Zhang Q, Yan J, Luo L, Zhang Q, Qiu A, Sun Y, Liang X, Expression of ILK in renal stroma is essential for multiple aspects of renal development. Am J Physiol Renal Physiol. 2018 Aug 1;315(2):F374-F385
1J:136180 Gontan C, de Munck A, Vermeij M, Grosveld F, Tibboel D, Rottier R, Sox2 is important for two crucial processes in lung development: branching morphogenesis and epithelial cell differentiation. Dev Biol. 2008 May 1;317(1):296-309
1J:319548 Gonzalez-Bohorquez D, Gallego Lopez IM, Jaeger BN, Pfammatter S, Bowers M, Semenkovich CF, Jessberger S, FASN-dependent de novo lipogenesis is required for brain development. Proc Natl Acad Sci U S A. 2022 Jan 11;119(2):e2112040119
1J:189063 Goodnough LH, Chang AT, Treloar C, Yang J, Scacheri PC, Atit RP, Twist1 mediates repression of chondrogenesis by beta-catenin to promote cranial bone progenitor specification. Development. 2012 Dec;139(23):4428-38
1J:229313 Goodnough LH, Dinuoscio GJ, Atit RP, Twist1 contributes to cranial bone initiation and dermal condensation by maintaining wnt signaling responsiveness. Dev Dyn. 2016 Feb;245(2):144-56
1J:226667 Goodnough LH, Dinuoscio GJ, Ferguson JW, Williams T, Lang RA, Atit RP, Distinct requirements for cranial ectoderm and mesenchyme-derived wnts in specification and differentiation of osteoblast and dermal progenitors. PLoS Genet. 2014 Feb;10(2):e1004152
1J:305179 Gray de Cristoforis A, Ferrari F, Clotman F, Vogel T, Differentiation and localization of interneurons in the developing spinal cord depends on DOT1L expression. Mol Brain. 2020 May 29;13(1):85
1J:98519 Grifone R, Demignon J, Houbron C, Souil E, Niro C, Seller MJ, Hamard G, Maire P, Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo. Development. 2005 May;132(9):2235-49
1J:191565 Grote P, Wittler L, Hendrix D, Koch F, Wahrisch S, Beisaw A, Macura K, Blass G, Kellis M, Werber M, Herrmann BG, The Tissue-Specific lncRNA Fendrr Is an Essential Regulator of Heart and Body Wall Development in the Mouse. Dev Cell. 2013 Jan 28;24(2):206-14
1J:224277 Han A, Zhao H, Li J, Pelikan R, Chai Y, ALK5-mediated transforming growth factor beta signaling in neural crest cells controls craniofacial muscle development via tissue-tissue interactions. Mol Cell Biol. 2014 Aug;34(16):3120-31
1J:253351 Hanley O, Zewdu R, Cohen LJ, Jung H, Lacombe J, Philippidou P, Lee DH, Selleri L, Dasen JS, Parallel Pbx-Dependent Pathways Govern the Coalescence and Fate of Motor Columns. Neuron. 2016 Sep 7;91(5):1005-1020
1J:203586 Harder JM, Ding Q, Fernandes KA, Cherry JD, Gan L, Libby RT, BCL2L1 (BCL-X) promotes survival of adult and developing retinal ganglion cells. Mol Cell Neurosci. 2012 Aug;51(1-2):53-9
1J:179804 Harrison SJ, Nishinakamura R, Jones KR, Monaghan AP, Sall1 regulates cortical neurogenesis and laminar fate specification in mice: implications for neural abnormalities in Townes-Brocks syndrome. Dis Model Mech. 2012 May;5(3):351-65
1J:298587 Hasenpusch-Theil K, Laclef C, Colligan M, Fitzgerald E, Howe K, Carroll E, Abrams SR, Reiter JF, Schneider-Maunoury S, Theil T, A transient role of the ciliary gene Inpp5e in controlling direct versus indirect neurogenesis in cortical development. Elife. 2020 Aug 25;9:e58162
1J:237535 Haugas M, Tikker L, Achim K, Salminen M, Partanen J, Gata2 and Gata3 regulate the differentiation of serotonergic and glutamatergic neuron subtypes of the dorsal raphe. Development. 2016 Dec 01;143(23):4495-4508
1J:219824 Hendley AM, Provost E, Bailey JM, Wang YJ, Cleveland MH, Blake D, Bittman RW, Roeser JC, Maitra A, Reynolds AB, Leach SD, p120 Catenin is required for normal tubulogenesis but not epithelial integrity in developing mouse pancreas. Dev Biol. 2015 Mar 1;399(1):41-53
1J:309228 Hill C, Jacobs B, Kennedy L, Rohde S, Zhou B, Baldwin S, Goudy S, Cranial neural crest deletion of VEGFa causes cleft palate with aberrant vascular and bone development. Cell Tissue Res. 2015 Sep;361(3):711-22
1J:175565 Hirose M, Niewiadomski P, Tse G, Chi GC, Dong H, Lee A, Carpenter EM, Waschek JA, Pituitary adenylyl cyclase-activating peptide counteracts hedgehog-dependent motor neuron production in mouse embryonic stem cell cultures. J Neurosci Res. 2011 Sep;89(9):1363-74
1J:264903 Hoang TV, Horowitz ER, Chaffee BR, Qi P, Flake RE, Bruney DG, Rasor BJ, Rosalez SE, Wagner BD, Robinson ML, Lens development requires DNMT1 but takes place normally in the absence of both DNMT3A and DNMT3B activity. Epigenetics. 2017 Jan 2;12(1):27-40
1J:264394 Hoffmann N, Weise SC, Marinaro F, Vogel T, De Pietri Tonelli D, DGCR8 Promotes Neural Progenitor Expansion and Represses Neurogenesis in the Mouse Embryonic Neocortex. Front Neurosci. 2018;12:281
1*J:314181 Holzman MA, Ryckman A, Finkelstein TM, Landry-Truchon K, Schindler KA, Bergmann JM, Jeannotte L, Mansfield JH, HOXA5 Participates in Brown Adipose Tissue and Epaxial Skeletal Muscle Patterning and in Brown Adipocyte Differentiation. Front Cell Dev Biol. 2021;9:632303
1J:78008 Honma Y, Araki T, Gianino S, Bruce A, Heuckeroth R, Johnson E, Milbrandt J, Artemin is a vascular-derived neurotropic factor for developing sympathetic neurons. Neuron. 2002 Jul 18;35(2):267-82
1J:139642 Hou Y, Li F, Karin M, Ostrowski MC, Analysis of the IKKbeta/NF-kappaB signaling pathway during embryonic angiogenesis. Dev Dyn. 2008 Sep 24;237(10):2926-2935
1J:218049 Houlihan SL, Feng Y, The scaffold protein Nde1 safeguards the brain genome during S phase of early neural progenitor differentiation. Elife. 2014;3:e03297
1J:326220 Hoye ML, Calviello L, Poff AJ, Ejimogu NE, Newman CR, Montgomery MD, Ou J, Floor SN, Silver DL, Aberrant cortical development is driven by impaired cell cycle and translational control in a DDX3X syndrome model. Elife. 2022 Jun 28;11:e78203
1J:243413 Hu JS, Vogt D, Lindtner S, Sandberg M, Silberberg SN, Rubenstein JLR, Coup-TF1 and Coup-TF2 control subtype and laminar identity of MGE-derived neocortical interneurons. Development. 2017 Aug 01;144(15):2837-2851
1J:207894 Hua ZL, Smallwood PM, Nathans J, Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons. Elife. 2013;2:e01482
1*J:208898 Huang CC, Orvis GD, Kwan KM, Behringer RR, Lhx1 is required in Mullerian duct epithelium for uterine development. Dev Biol. 2014 May 15;389(2):124-36
1J:152851 Huang X, Ketova T, Fleming JT, Wang H, Dey SK, Litingtung Y, Chiang C, Sonic hedgehog signaling regulates a novel epithelial progenitor domain of the hindbrain choroid plexus. Development. 2009 Aug;136(15):2535-43
1J:229246 Huh SH, Warchol ME, Ornitz DM, Cochlear progenitor number is controlled through mesenchymal FGF receptor signaling. Elife. 2015;4
1J:308554 Humpton TJ, Nomura K, Weber J, Magnussen HM, Hock AK, Nixon C, Dhayade S, Stevenson D, Huang DT, Strathdee D, Blyth K, Vousden KH, Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice. Genes Dev. 2021 Jan 1;35(1-2):117-132
1*J:326587 Hurley S, Mohan C, Suetterlin P, Ellingford R, Riegman KLH, Ellegood J, Caruso A, Michetti C, Brock O, Evans R, Rudari F, Delogu A, Scattoni ML, Lerch JP, Fernandes C, Basson MA, Distinct, dosage-sensitive requirements for the autism-associated factor CHD8 during cortical development. Mol Autism. 2021 Feb 24;12(1):16
1J:150882 Ichikawa H, Terayama R, Yamaai T, Jacobowitz DM, Qiu F, Xiang M, Sugimoto T, Brn-3a deficiency transiently increases expression of calbindin D-28 k and calretinin in the trigeminal ganglion during embryonic development. Cell Mol Neurobiol. 2009 Jul;29(5):691-8
1J:210997 Ihermann-Hella A, Lume M, Miinalainen IJ, Pirttiniemi A, Gui Y, Peranen J, Charron J, Saarma M, Costantini F, Kuure S, Mitogen-activated protein kinase (MAPK) pathway regulates branching by remodeling epithelial cell adhesion. PLoS Genet. 2014 Mar;10(3):e1004193
1J:155983 Ikeda T, Kanazawa T, Otsuka S, Ichii O, Hashimoto Y, Kon Y, Expression of caspase family and muscle- and apoptosis-specific genes during skeletal myogenesis in mouse embryo. J Vet Med Sci. 2009 Sep;71(9):1161-8
1*J:171508 Ikegami D, Akiyama H, Suzuki A, Nakamura T, Nakano T, Yoshikawa H, Tsumaki N, Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways. Development. 2011 Apr;138(8):1507-19
1J:219422 Insolera R, Bazzi H, Shao W, Anderson KV, Shi SH, Cortical neurogenesis in the absence of centrioles. Nat Neurosci. 2014 Nov;17(11):1528-35
1J:157262 Ioannides AS, Massa V, Ferraro E, Cecconi F, Spitz L, Henderson DJ, Copp AJ, Foregut separation and tracheo-oesophageal malformations: the role of tracheal outgrowth, dorso-ventral patterning and programmed cell death. Dev Biol. 2010 Jan 15;337(2):351-62
1J:231591 Iskusnykh IY, Steshina EY, Chizhikov VV, Loss of Ptf1a Leads to a Widespread Cell-Fate Misspecification in the Brainstem, Affecting the Development of Somatosensory and Viscerosensory Nuclei. J Neurosci. 2016 Mar 2;36(9):2691-710
1J:173361 Itoh A, Horiuchi M, Wakayama K, Xu J, Bannerman P, Pleasure D, Itoh T, ZPK/DLK, a mitogen-activated protein kinase kinase kinase, is a critical mediator of programmed cell death of motoneurons. J Neurosci. 2011 May 18;31(20):7223-8
1J:128441 Jacob J, Ferri AL, Milton C, Prin F, Pla P, Lin W, Gavalas A, Ang SL, Briscoe J, Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis. Nat Neurosci. 2007 Nov;10(11):1433-9
1J:152424 Jacob J, Storm R, Castro DS, Milton C, Pla P, Guillemot F, Birchmeier C, Briscoe J, Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain. Development. 2009 Jul;136(14):2477-85
1J:205043 Janisch KM, Vock VM, Fleming MS, Shrestha A, Grimsley-Myers CM, Rasoul BA, Neale SA, Cupp TD, Kinchen JM, Liem KF Jr, Dwyer ND, The vertebrate-specific Kinesin-6, Kif20b, is required for normal cytokinesis of polarized cortical stem cells and cerebral cortex size. Development. 2013 Dec;140(23):4672-82
1J:191667 Jayakody SA, Andoniadou CL, Gaston-Massuet C, Signore M, Cariboni A, Bouloux PM, Le Tissier P, Pevny LH, Dattani MT, Martinez-Barbera JP, SOX2 regulates the hypothalamic-pituitary axis at multiple levels. J Clin Invest. 2012 Oct 1;122(10):3635-46
1J:101177 Jiang Y, de Bruin A, Caldas H, Fangusaro J, Hayes J, Conway EM, Robinson ML, Altura RA, Essential role for survivin in early brain development. J Neurosci. 2005 Jul 27;25(30):6962-70
1J:199663 Jiang Y, Ding Q, Xie X, Libby RT, Lefebvre V, Gan L, Transcription factors SOX4 and SOX11 function redundantly to regulate the development of mouse retinal ganglion cells. J Biol Chem. 2013 Jun 21;288(25):18429-38
1J:304136 Journiac N, Gilabert-Juan J, Cipriani S, Benit P, Liu X, Jacquier S, Faivre V, Delahaye-Duriez A, Csaba Z, Hourcade T, Melinte E, Lebon S, Violle-Poirsier C, Oury JF, Adle-Biassette H, Wang ZQ, Mani S, Rustin P, Gressens P, Nardelli J, Cell Metabolic Alterations due to Mcph1 Mutation in Microcephaly. Cell Rep. 2020 Apr 14;31(2):107506
1J:259920 Ju J, Liu Q, Zhang Y, Liu Y, Jiang M, Zhang L, He X, Peng C, Zheng T, Lu QR, Li H, Olig2 regulates Purkinje cell generation in the early developing mouse cerebellum. Sci Rep. 2016 Jul 29;6:30711
1J:256001 Jung EM, Moffat JJ, Liu J, Dravid SM, Gurumurthy CB, Kim WY, Arid1b haploinsufficiency disrupts cortical interneuron development and mouse behavior. Nat Neurosci. 2017 Dec;20(12):1694-1707
1J:308827 Kaiser K, Jang A, Kompanikova P, Lun MP, Prochazka J, Machon O, Dani N, Prochazkova M, Laurent B, Gyllborg D, van Amerongen R, Fame RM, Gupta S, Wu F, Barker RA, Bukova I, Sedlacek R, Kozmik Z, Arenas E, Lehtinen MK, Bryja V, MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus. Development. 2021 May 15;148(10):dev192054
1J:144171 Kao SC, Wu H, Xie J, Chang CP, Ranish JA, Graef IA, Crabtree GR, Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation. Science. 2009 Jan 30;323(5914):651-4
1J:212924 Katyal S, Lee Y, Nitiss KC, Downing SM, Li Y, Shimada M, Zhao J, Russell HR, Petrini JH, Nitiss JL, McKinnon PJ, Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes. Nat Neurosci. 2014 Jun;17(6):813-21
1J:331939 Keil JM, Doyle DZ, Qalieh A, Lam MM, Funk OH, Qalieh Y, Shi L, Mohan N, Sorel A, Kwan KY, Symmetric neural progenitor divisions require chromatin-mediated homologous recombination DNA repair by Ino80. Nat Commun. 2020 Jul 31;11(1):3839
1J:171536 Kersigo J, D'Angelo A, Gray BD, Soukup GA, Fritzsch B, The role of sensory organs and the forebrain for the development of the craniofacial shape as revealed by Foxg1-cre-mediated microRNA loss. Genesis. 2011 Apr;49(4):326-41
1J:289657 Kikkawa T, Sakayori N, Yuuki H, Katsuyama Y, Matsuzaki F, Konno D, Abe T, Kiyonari H, Osumi N, Dmrt genes participate in the development of Cajal-Retzius cells derived from the cortical hem in the telencephalon. Dev Dyn. 2020 Jun;249(6):698-710
1J:197212 Kim HJ, Woo HM, Ryu J, Bok J, Kim JW, Choi SB, Park MH, Park HY, Koo SK, Conditional deletion of pten leads to defects in nerve innervation and neuronal survival in inner ear development. PLoS One. 2013;8(2):e55609
1J:303001 Kist M, Komuves LG, Goncharov T, Dugger DL, Yu C, Roose-Girma M, Newton K, Webster JD, Vucic D, Impaired RIPK1 ubiquitination sensitizes mice to TNF toxicity and inflammatory cell death. Cell Death Differ. 2021 Mar;28(3):985-1000
1J:263685 Kitami K, Kitami M, Kaku M, Wang B, Komatsu Y, BRCA1 and BRCA2 tumor suppressors in neural crest cells are essential for craniofacial bone development. PLoS Genet. 2018 May;14(5):e1007340
1J:208421 Klimova L, Kozmik Z, Stage-dependent requirement of neuroretinal Pax6 for lens and retina development. Development. 2014 Mar;141(6):1292-302
1J:270202 Kogata N, Oliemuller E, Wansbury O, Howard BA, Neuregulin-3 regulates epithelial progenitor cell positioning and specifies mammary phenotype. Stem Cells Dev. 2014 Nov 15;23(22):2758-70
1*J:333188 Koizumi M, Eto H, Saeki M, Seki M, Fukushima T, Mukai S, Ide H, Sera Y, Iwasaki M, Suzuki Y, Tohei A, Kishi Y, Honda H, UTX deficiency in neural stem/progenitor cells results in impaired neural development, fetal ventriculomegaly, and postnatal death. FASEB J. 2022 Dec;36(12):e22662
1J:192860 Kosaka Y, Cieslik KA, Li L, Lezin G, Maguire CT, Saijoh Y, Toyo-oka K, Gambello MJ, Vatta M, Wynshaw-Boris A, Baldini A, Yost HJ, Brunelli L, 14-3-3epsilon plays a role in cardiac ventricular compaction by regulating the cardiomyocyte cell cycle. Mol Cell Biol. 2012 Dec;32(24):5089-102
1J:241960 Koshida R, Oishi H, Hamada M, Takei Y, Takahashi S, MafB is required for development of the hindbrain choroid plexus. Biochem Biophys Res Commun. 2017 Jan 29;483(1):288-293
1J:166127 Kuhnert F, Mancuso MR, Shamloo A, Wang HT, Choksi V, Florek M, Su H, Fruttiger M, Young WL, Heilshorn SC, Kuo CJ, Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124. Science. 2010 Nov 12;330(6006):985-9
1J:49088 Kuida K, Haydar TF, Kuan CY, Gu Y, Taya C, Karasuyama H, Su MS, Rakic P, Flavell RA, Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell. 1998 Aug 7;94(3):325-37
1*J:169107 Kunwar AJ, Rickmann M, Backofen B, Browski SM, Rosenbusch J, Schoning S, Fleischmann T, Krieglstein K, Fischer von Mollard G, Lack of the endosomal SNAREs vti1a and vti1b led to significant impairments in neuronal development. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2575-80
1*J:203791 Kuracha MR, Siefker E, Licht JD, Govindarajan V, Spry1 and Spry2 are necessary for eyelid closure. Dev Biol. 2013 Nov 15;383(2):227-38
1J:100024 Kuwako K, Hosokawa A, Nishimura I, Uetsuki T, Yamada M, Nada S, Okada M, Yoshikawa K, Disruption of the paternal necdin gene diminishes TrkA signaling for sensory neuron survival. J Neurosci. 2005 Jul 27;25(30):7090-9
1J:335074 Kuzelova A, Dupacova N, Antosova B, Sunny SS, Kozmik Z Jr, Paces J, Skoultchi AI, Stopka T, Kozmik Z, Chromatin Remodeling Enzyme Snf2h Is Essential for Retinal Cell Proliferation and Photoreceptor Maintenance. Cells. 2023 Mar 28;12(7)
1J:304308 Kweon H, Jung WB, Im GH, Ryoo J, Lee JH, Do H, Choi Y, Song YH, Jung H, Park H, Qiu LR, Ellegood J, Shim HJ, Yang E, Kim H, Lerch JP, Lee SH, Chung WS, Kim D, Kim SG, Kim E, Excitatory neuronal CHD8 in the regulation of neocortical development and sensory-motor behaviors. Cell Rep. 2021 Feb 23;34(8):108780
1J:240003 Laguesse S, Creppe C, Nedialkova DD, Prevot PP, Borgs L, Huysseune S, Franco B, Duysens G, Krusy N, Lee G, Thelen N, Thiry M, Close P, Chariot A, Malgrange B, Leidel SA, Godin JD, Nguyen L, A Dynamic Unfolded Protein Response Contributes to the Control of Cortical Neurogenesis. Dev Cell. 2015 Dec 07;35(5):553-67
1J:182759 Lahti L, Peltopuro P, Piepponen TP, Partanen J, Cell-autonomous FGF signaling regulates anteroposterior patterning and neuronal differentiation in the mesodiencephalic dopaminergic progenitor domain. Development. 2012 Mar;139(5):894-905
1J:235955 Laitman BM, Asp L, Mariani JN, Zhang J, Liu J, Sawai S, Chapouly C, Horng S, Kramer EG, Mitiku N, Loo H, Burlant N, Pedre X, Hara Y, Nudelman G, Zaslavsky E, Lee YM, Braun DA, Lu QR, Narla G, Raine CS, Friedman SL, Casaccia P, John GR, The Transcriptional Activator Kruppel-like Factor-6 Is Required for CNS Myelination. PLoS Biol. 2016 May;14(5):e1002467
1J:189922 Lallemend F, Sterzenbach U, Hadjab-Lallemend S, Aquino JB, Castelo-Branco G, Sinha I, Villaescusa JC, Levanon D, Wang Y, Franck MC, Kharchenko O, Adameyko I, Linnarsson S, Groner Y, Turner E, Ernfors P, Positional differences of axon growth rates between sensory neurons encoded by Runx3. EMBO J. 2012 Sep 12;31(18):3718-29
1J:254235 Lanctot AA, Guo Y, Le Y, Edens BM, Nowakowski RS, Feng Y, Loss of Brap Results in Premature G1/S Phase Transition and Impeded Neural Progenitor Differentiation. Cell Rep. 2017 Aug 1;20(5):1148-1160
1J:197131 Lanctot AA, Peng CY, Pawlisz AS, Joksimovic M, Feng Y, Spatially dependent dynamic MAPK modulation by the nde1-lis1-brap complex patterns Mammalian CNS. Dev Cell. 2013 May 13;25(3):241-55
1J:304297 Landy MA, Goyal M, Casey KM, Liu C, Lai HC, Loss of Prdm12 during development, but not in mature nociceptors, causes defects in pain sensation. Cell Rep. 2021 Mar 30;34(13):108913
1J:179496 Lang B, Zhao L, Cai L, McKie L, Forrester JV, McCaig CD, Jackson IJ, Shen S, GABAergic amacrine cells and visual function are reduced in PAC1 transgenic mice. Neuropharmacology. 2010 Jan;58(1):215-25
1J:272249 Laporte MH, Chatellard C, Vauchez V, Hemming FJ, Deloulme JC, Vossier F, Blot B, Fraboulet S, Sadoul R, Alix is required during development for normal growth of the mouse brain. Sci Rep. 2017 Mar 21;7:44767
1J:228865 Law C, Schaan Profes M, Levesque M, Kaltschmidt JA, Verhage M, Kania A, Normal Molecular Specification and Neurodegenerative Disease-Like Death of Spinal Neurons Lacking the SNARE-Associated Synaptic Protein Munc18-1. J Neurosci. 2016 Jan 13;36(2):561-76
1J:264469 Lee JA, Wang Z, Sambo D, Bunting KD, Pallas DC, Global loss of leucine carboxyl methyltransferase-1 causes severe defects in fetal liver hematopoiesis. J Biol Chem. 2018 Jun 22;293(25):9636-9650
1J:184232 Lee K, Tan J, Morris MB, Rizzoti K, Hughes J, Cheah PS, Felquer F, Liu X, Piltz S, Lovell-Badge R, Thomas PQ, Congenital hydrocephalus and abnormal subcommissural organ development in Sox3 transgenic mice. PLoS One. 2012;7(1):e29041
1J:301834 Li G, Xu C, Lin X, Qu L, Xia D, Hongdu B, Xia Y, Wang X, Lou Y, He Q, Ma D, Chen Y, Deletion of Pdcd5 in mice led to the deficiency of placenta development and embryonic lethality. Cell Death Dis. 2017 May 25;8(5):e2811
1J:275908 Li H, Jakobson M, Ola R, Gui Y, Kumar A, Sipila P, Sariola H, Kuure S, Andressoo JO, Development of the urogenital system is regulated via the 3'UTR of GDNF. Sci Rep. 2019 Mar 28;9(1):5302
1J:297798 Li L, Ghorbani M, Weisz-Hubshman M, Rousseau J, Thiffault I, Schnur RE, Breen C, Oegema R, Weiss MM, Waisfisz Q, Welner S, Kingston H, Hills JA, Boon EM, Basel-Salmon L, Konen O, Goldberg-Stern H, Bazak L, Tzur S, Jin J, Bi X, Bruccoleri M, McWalter K, Cho MT, Scarano M, Schaefer GB, Brooks SS, Hughes SS, van Gassen KLI, van Hagen JM, Pandita TK, Agrawal PB, Campeau PM, Yang XJ, Lysine acetyltransferase 8 is involved in cerebral development and syndromic intellectual disability. J Clin Invest. 2020 Mar 2;130(3):1431-1445
1J:264403 Li Q, Jiao J, Li H, Wan H, Zheng C, Cai J, Bao S, Histone arginine methylation by Prmt5 is required for lung branching morphogenesis through repression of BMP signaling. J Cell Sci. 2018 Jul 25;131(14):jcs217406
1*J:316150 Li R, Yang YG, Gao Y, Wang ZQ, Tong WM, A distinct response to endogenous DNA damage in the development of Nbs1-deficient cortical neurons. Cell Res. 2012 May;22(5):859-72
1J:317364 Li SY, Gu X, Heinrich A, Hurley EG, Capel B, DeFalco T, Loss of Mafb and Maf distorts myeloid cell ratios and disrupts fetal mouse testis vascularization and organogenesis. Biol Reprod. 2021 Oct 11;105(4):958-975
1*J:151925 Li Y, Piatigorsky J, Targeted deletion of Dicer disrupts lens morphogenesis, corneal epithelium stratification, and whole eye development. Dev Dyn. 2009 Sep;238(9):2388-400
1J:194076 Liang H, Xiao G, Yin H, Hippenmeyer S, Horowitz JM, Ghashghaei HT, Neural development is dependent on the function of specificity protein 2 in cell cycle progression. Development. 2013 Feb 1;140(3):552-61
1J:166964 Lin L, Lee VM, Wang Y, Lin JS, Sock E, Wegner M, Lei L, Sox11 regulates survival and axonal growth of embryonic sensory neurons. Dev Dyn. 2011 Jan;240(1):52-64
1J:304629 Little JN, McNeely KC, Michel N, Bott CJ, Lettieri KS, Hecht MR, Martin SA, Dwyer ND, Loss of Coiled-Coil Protein Cep55 Impairs Neural Stem Cell Abscission and Results in p53-Dependent Apoptosis in Developing Cortex. J Neurosci. 2021 Apr 14;41(15):3344-3365
1J:160533 Lizarraga SB, Margossian SP, Harris MH, Campagna DR, Han AP, Blevins S, Mudbhary R, Barker JE, Walsh CA, Fleming MD, Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors. Development. 2010 Jun;137(11):1907-17
1J:239944 Lorenzen SM, Duggan A, Osipovich AB, Magnuson MA, Garcia-Anoveros J, Insm1 promotes neurogenic proliferation in delaminated otic progenitors. Mech Dev. 2015 Nov;138 Pt 3:233-45
1J:346057 Lu D, Zhi Y, Su H, Lin X, Lin J, Shi Y, Yi W, Hong C, Zhang T, Fu Z, Chen LY, Zhao Z, Li R, Xu Z, Chen W, Wang N, Xu D, ESCRT-I protein UBAP1 controls ventricular expansion and cortical neurogenesis via modulating adherens junctions of radial glial cells. Cell Rep. 2024 Feb 24;43(3):113818
1J:206284 Lu KM, Evans SM, Hirano S, Liu FC, Dual role for Islet-1 in promoting striatonigral and repressing striatopallidal genetic programs to specify striatonigral cell identity. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E168-77
1J:288654 Lun MP, Shannon ML, Keles S, Reisli I, Luche N, Ryan D, Capuder K, Notarangelo LD, Lehtinen MK, Spatiotemporal Gradient of Cortical Neuron Death Contributes to Microcephaly in Knock-In Mouse Model of Ligase 4 Syndrome. Am J Pathol. 2019 Dec;189(12):2440-2449
1J:199588 Luo XJ, Deng M, Xie X, Huang L, Wang H, Jiang L, Liang G, Hu F, Tieu R, Chen R, Gan L, GATA3 controls the specification of prosensory domain and neuronal survival in the mouse cochlea. Hum Mol Genet. 2013 Sep 15;22(18):3609-23
1J:85603 Machold R, Hayashi S, Rutlin M, Muzumdar MD, Nery S, Corbin JG, Gritli-Linde A, Dellovade T, Porter JA, Rubin LL, Dudek H, McMahon AP, Fishell G, Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches. Neuron. 2003 Sep 11;39(6):937-50
1J:273447 Magalhaes AC, Rivera C, NKCC1-Deficiency Results in Abnormal Proliferation of Neural Progenitor Cells of the Lateral Ganglionic Eminence. Front Cell Neurosci. 2016;10:200
1J:181009 Magenheim J, Ilovich O, Lazarus A, Klochendler A, Ziv O, Werman R, Hija A, Cleaver O, Mishani E, Keshet E, Dor Y, Blood vessels restrain pancreas branching, differentiation and growth. Development. 2011 Nov;138(21):4743-52
1J:215515 Magnani D, Hasenpusch-Theil K, Theil T, Gli3 controls subplate formation and growth of cortical axons. Cereb Cortex. 2013 Nov;23(11):2542-51
1J:284120 Mahamud MR, Geng X, Ho YC, Cha B, Kim Y, Ma J, Chen L, Myers G, Camper S, Mustacich D, Witte M, Choi D, Hong YK, Chen H, Varshney G, Engel JD, Wang S, Kim TH, Lim KC, Srinivasan RS, GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126. Development. 2019 Nov 5;146(21):dev184218
1*J:240595 Mao H, Brown HE, Silver DL, Mouse models of Casc3 reveal developmental functions distinct from other components of the exon junction complex. RNA. 2017 Jan;23(1):23-31
1*J:235650 Mao H, McMahon JJ, Tsai YH, Wang Z, Silver DL, Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly. PLoS Genet. 2016 Sep;12(9):e1006282
1J:221648 Mao H, Pilaz LJ, McMahon JJ, Golzio C, Wu D, Shi L, Katsanis N, Silver DL, Rbm8a haploinsufficiency disrupts embryonic cortical development resulting in microcephaly. J Neurosci. 2015 May 6;35(18):7003-18
1J:160363 Mao J, Kim BM, Rajurkar M, Shivdasani RA, McMahon AP, Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract. Development. 2010 May;137(10):1721-9
1J:239790 Marcos S, Gonzalez-Lazaro M, Beccari L, Carramolino L, Martin-Bermejo MJ, Amarie O, Mateos-San Martin D, Torroja C, Bogdanovic O, Doohan R, Puk O, Hrabe de Angelis M, Graw J, Gomez-Skarmeta JL, Casares F, Torres M, Bovolenta P, Meis1 coordinates a network of genes implicated in eye development and microphthalmia. Development. 2015 Sep 01;142(17):3009-20
1J:338454 Marfull-Oromi P, Fleitas C, Zammou B, Rocandio D, Ballester-Lurbe B, Terrado J, Perez-Roger I, Espinet C, Egea J, Genetic ablation of the Rho GTPase Rnd3 triggers developmental defects in internal capsule and the globus pallidus formation. J Neurochem. 2021 Jul;158(2):197-216
1J:241293 Marinaro F, Marzi MJ, Hoffmann N, Amin H, Pelizzoli R, Niola F, Nicassio F, De Pietri Tonelli D, MicroRNA-independent functions of DGCR8 are essential for neocortical development and TBR1 expression. EMBO Rep. 2017 Apr;18(4):603-618
1J:210514 Martinez P, Ferrara-Romeo I, Flores JM, Blasco MA, Essential role for the TRF2 telomere protein in adult skin homeostasis. Aging Cell. 2014 Aug;13(4):656-68
1J:229014 Marty-Santos L, Cleaver O, Pdx1 regulates pancreas tubulogenesis and E-cadherin expression. Development. 2016 Jan 1;143(1):101-12
1J:112183 Mason HA, Rakowiecki SM, Gridley T, Fishell G, Loss of notch activity in the developing central nervous system leads to increased cell death. Dev Neurosci. 2006;28(1-2):49-57
1J:330324 Masuda T, Amann L, Monaco G, Sankowski R, Staszewski O, Krueger M, Del Gaudio F, He L, Paterson N, Nent E, Fernandez-Klett F, Yamasaki A, Frosch M, Fliegauf M, Bosch LFP, Ulupinar H, Hagemeyer N, Schreiner D, Dorrier C, Tsuda M, Grothe C, Joutel A, Daneman R, Betsholtz C, Lendahl U, Knobeloch KP, Lammermann T, Priller J, Kierdorf K, Prinz M, Specification of CNS macrophage subsets occurs postnatally in defined niches. Nature. 2022 Apr;604(7907):740-748
1J:338931 Matsui Y, Djekidel MN, Lindsay K, Samir P, Connolly N, Wu G, Yang X, Fan Y, Xu B, Peng JC, SNIP1 and PRC2 coordinate cell fates of neural progenitors during brain development. Nat Commun. 2023 Aug 8;14(1):4754
1J:178174 Matsumoto A, Susaki E, Onoyama I, Nakayama K, Hoshino M, Nakayama KI, Deregulation of the p57-E2F1-p53 axis results in nonobstructive hydrocephalus and cerebellar malformation in mice. Mol Cell Biol. 2011 Oct;31(20):4176-92
1J:179882 Mead TJ, Yutzey KE, Notch pathway regulation of neural crest cell development in vivo. Dev Dyn. 2012 Feb;241(2):376-89
1*J:175228 Medeiros LA, Dennis LM, Gill ME, Houbaviy H, Markoulaki S, Fu D, White AC, Kirak O, Sharp PA, Page DC, Jaenisch R, Mir-290-295 deficiency in mice results in partially penetrant embryonic lethality and germ cell defects. Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14163-8
1J:284129 Meier S, Alfonsi F, Kurniawan ND, Milne MR, Kasherman MA, Delogu A, Piper M, Coulson EJ, The p75 neurotrophin receptor is required for the survival of neuronal progenitors and normal formation of the basal forebrain, striatum, thalamus and neocortex. Development. 2019 Sep 18;146(18):dev181933
1J:177092 Mishima Y, Miyagi S, Saraya A, Negishi M, Endoh M, Endo TA, Toyoda T, Shinga J, Katsumoto T, Chiba T, Yamaguchi N, Kitabayashi I, Koseki H, Iwama A, The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis. Blood. 2011 Sep 1;118(9):2443-53
1J:212863 Mommersteeg MT, Andrews WD, Ypsilanti AR, Zelina P, Yeh ML, Norden J, Kispert A, Chedotal A, Christoffels VM, Parnavelas JG, Slit-roundabout signaling regulates the development of the cardiac systemic venous return and pericardium. Circ Res. 2013 Feb 1;112(3):465-75
1J:141338 Mommersteeg MT, Brown NA, Prall OW, de Gier-de Vries C, Harvey RP, Moorman AF, Christoffels VM, Pitx2c and Nkx2-5 are required for the formation and identity of the pulmonary myocardium. Circ Res. 2007 Oct 26;101(9):902-9
1J:244269 Mommersteeg MT, Yeh ML, Parnavelas JG, Andrews WD, Disrupted Slit-Robo signalling results in membranous ventricular septum defects and bicuspid aortic valves. Cardiovasc Res. 2015 Apr 01;106(1):55-66
1J:338207 Moreau MX, Saillour Y, Elorriaga V, Bouloudi B, Delberghe E, Deutsch Guerrero T, Ochandorena-Saa A, Maeso-Alonso L, Marques MM, Marin MC, Spassky N, Pierani A, Causeret F, Repurposing of the multiciliation gene regulatory network in fate specification of Cajal-Retzius neurons. Dev Cell. 2023 Jun 7;
1J:285894 Murakami S, Suzuki T, Yokoyama W, Yagi S, Matsumura K, Nakajima Y, Harigae H, Fukamizu A, Motohashi H, Nucleomethylin deficiency impairs embryonic erythropoiesis. J Biochem. 2018 May 1;163(5):413-423
1*J:241850 Naiman N, Fujioka K, Fujino M, Valerius MT, Potter SS, McMahon AP, Kobayashi A, Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development. Dev Cell. 2017 May 22;41(4):349-365.e3
1J:228583 Nandadasa S, Nelson CM, Apte SS, ADAMTS9-Mediated Extracellular Matrix Dynamics Regulates Umbilical Cord Vascular Smooth Muscle Differentiation and Rotation. Cell Rep. 2015 Jun 16;11(10):1519-28
1J:314576 Narayanan R, Pirouz M, Kerimoglu C, Pham L, Wagener RJ, Kiszka KA, Rosenbusch J, Seong RH, Kessel M, Fischer A, Stoykova A, Staiger JF, Tuoc T, Loss of BAF (mSWI/SNF) Complexes Causes Global Transcriptional and Chromatin State Changes in Forebrain Development. Cell Rep. 2015 Dec 1;13(9):1842-54
1J:229930 Nechiporuk T, McGann J, Mullendorff K, Hsieh J, Wurst W, Floss T, Mandel G, The REST remodeling complex protects genomic integrity during embryonic neurogenesis. Elife. 2016;5:e09584
1J:137017 Nekrep N, Wang J, Miyatsuka T, German MS, Signals from the neural crest regulate beta-cell mass in the pancreas. Development. 2008 Jun;135(12):2151-60
1J:253982 Norlin S, Parekh V, Edlund H, The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival. Development. 2018 Jan 3;145(1):dev154468
1J:176531 Nowakowski TJ, Mysiak KS, Pratt T, Price DJ, Functional dicer is necessary for appropriate specification of radial glia during early development of mouse telencephalon. PLoS One. 2011;6(8):e23013
1J:215563 Oberbeck N, Langevin F, King G, de Wind N, Crossan GP, Patel KJ, Maternal aldehyde elimination during pregnancy preserves the fetal genome. Mol Cell. 2014 Sep 18;55(6):807-17
1J:285050 Ochi S, Imaizumi Y, Shimojo H, Miyachi H, Kageyama R, Oscillatory expression of Hes1 regulates cell proliferation and neuronal differentiation in the embryonic brain. Development. 2020 Feb 26;147(4):dev182204
1J:191206 Okamura D, Maeda I, Taniguchi H, Tokitake Y, Ikeda M, Ozato K, Mise N, Abe K, Noce T, Izpisua Belmonte JC, Matsui Y, Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells. Genes Dev. 2012 Nov 15;26(22):2477-82
1J:178908 Okano T, Xuan S, Kelley MW, Insulin-like growth factor signaling regulates the timing of sensory cell differentiation in the mouse cochlea. J Neurosci. 2011 Dec 7;31(49):18104-18
1J:284130 Okuhara S, Birjandi AA, Adel Al-Lami H, Sagai T, Amano T, Shiroishi T, Xavier GM, Liu KJ, Cobourne MT, Iseki S, Temporospatial sonic hedgehog signalling is essential for neural crest-dependent patterning of the intrinsic tongue musculature. Development. 2019 Nov 12;146(21):dev180075
1J:160534 Ono Y, Nakatani T, Minaki Y, Kumai M, The basic helix-loop-helix transcription factor Nato3 controls neurogenic activity in mesencephalic floor plate cells. Development. 2010 Jun;137(11):1897-906
1J:336091 Ono Y, Schlesinger S, Fukunaga K, Yambe S, Sato T, Sasaki T, Shukunami C, Asahara H, Inui M, Scleraxis-lineage cells are required for correct muscle patterning. Development. 2023 May 15;150(10):dev201101
1*J:245773 Paikari A, D Belair C, Saw D, Blelloch R, The eutheria-specific miR-290 cluster modulates placental growth and maternal-fetal transport. Development. 2017 Oct 15;144(20):3731-3743
1J:71196 Panchision DM, Pickel JM, Studer L, Lee SH, Turner PA, Hazel TG, McKay RD, Sequential actions of BMP receptors control neural precursor cell production and fate. Genes Dev. 2001 Aug 15;15(16):2094-110
1J:207293 Pao GM, Zhu Q, Perez-Garcia CG, Chou SJ, Suh H, Gage FH, O'Leary DD, Verma IM, Role of BRCA1 in brain development. Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):E1240-8
1J:239772 Parada C, Han D, Grimaldi A, Sarrion P, Park SS, Pelikan R, Sanchez-Lara PA, Chai Y, Disruption of the ERK/MAPK pathway in neural crest cells as a potential cause of Pierre Robin sequence. Development. 2015 Nov 01;142(21):3734-45
1J:320719 Parichha A, Suresh V, Chatterjee M, Kshirsagar A, Ben-Reuven L, Olender T, Taketo MM, Radosevic V, Bobic-Rasonja M, Trnski S, Holtzman MJ, Jovanov-Milosevic N, Reiner O, Tole S, Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate. Nat Commun. 2022 Feb 2;13(1):633
1J:227024 Paris ND, Coles GL, Ackerman KG, Wt1 and beta-catenin cooperatively regulate diaphragm development in the mouse. Dev Biol. 2015 Nov 1;407(1):40-56
1J:168641 Park D, Xiang AP, Mao FF, Zhang L, Di CG, Liu XM, Shao Y, Ma BF, Lee JH, Ha KS, Walton N, Lahn BT, Nestin is required for the proper self-renewal of neural stem cells. Stem Cells. 2010 Dec;28(12):2162-71
1J:121096 Parras CM, Hunt C, Sugimori M, Nakafuku M, Rowitch D, Guillemot F, The proneural gene Mash1 specifies an early population of telencephalic oligodendrocytes. J Neurosci. 2007 Apr 18;27(16):4233-42
1J:176574 Peng C, Aron L, Klein R, Li M, Wurst W, Prakash N, Le W, Pitx3 Is a Critical Mediator of GDNF-Induced BDNF Expression in Nigrostriatal Dopaminergic Neurons. J Neurosci. 2011 Sep 7;31(36):12802-12815
1J:188279 Peng C, Li N, Ng YK, Zhang J, Meier F, Theis FJ, Merkenschlager M, Chen W, Wurst W, Prakash N, A Unilateral Negative Feedback Loop Between miR-200 microRNAs and Sox2/E2F3 Controls Neural Progenitor Cell-Cycle Exit and Differentiation. J Neurosci. 2012 Sep 19;32(38):13292-13308
1J:191071 Petzold KM, Naumann H, Spagnoli FM, Rho signalling restriction by the RhoGAP Stard13 integrates growth and morphogenesis in the pancreas. Development. 2013 Jan 1;140(1):126-35
1J:294004 Piprek RP, Kolasa M, Podkowa D, Kloc M, Kubiak JZ, N-Cadherin Is Critical for the Survival of Germ Cells, the Formation of Steroidogenic Cells, and the Architecture of Developing Mouse Gonads. Cells. 2019 Dec 11;8(12):1610
1*J:325976 Piprek RP, Rams-Pociecha I, Zdanowski R, Kloc M, Kubiak JZ, Desmoplakin (Dsp) conditional knockout in NR5A1+ somatic cells affects germ cell survival in developing mouse gonads. Reproduction. 2022 Feb 24;163(4):199-207
1J:255488 Premarathne S, Murtaza M, Matigian N, Jolly LA, Wood SA, Loss of Usp9x disrupts cell adhesion, and components of the Wnt and Notch signaling pathways in neural progenitors. Sci Rep. 2017 Aug 14;7(1):8109
1J:162560 Qu Y, Glasco DM, Zhou L, Sawant A, Ravni A, Fritzsch B, Damrau C, Murdoch JN, Evans S, Pfaff SL, Formstone C, Goffinet AM, Chandrasekhar A, Tissir F, Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice. J Neurosci. 2010 Jul 14;30(28):9392-401
1J:345597 Quilez S, Dumontier E, Baim C, Kam J, Cloutier JF, Loss of Neogenin alters branchial arch development and leads to craniofacial skeletal defects. Front Cell Dev Biol. 2024;12:1256465
1J:260927 Rahim RS, St John JA, Crane DI, Meedeniya ACB, Impaired neurogenesis and associated gliosis in mouse brain with PEX13 deficiency. Mol Cell Neurosci. 2018 Apr;88:16-32
1J:241275 Reginensi A, Enderle L, Gregorieff A, Johnson RL, Wrana JL, McNeill H, A critical role for NF2 and the Hippo pathway in branching morphogenesis. Nat Commun. 2016 Aug 02;7:12309
1J:224142 Reginensi A, Hoshi M, Boualia SK, Bouchard M, Jain S, McNeill H, Yap and Taz are required for Ret-dependent urinary tract morphogenesis. Development. 2015 Aug 1;142(15):2696-703
1J:188151 Repetto E, Briata P, Kuziner N, Harfe BD, McManus MT, Gherzi R, Rosenfeld MG, Trabucchi M, Let-7b/c enhance the stability of a tissue-specific mRNA during mammalian organogenesis as part of a feedback loop involving KSRP. PLoS Genet. 2012 Jul;8(7):e1002823
1*J:206632 Roberts JM, Ennajdaoui H, Edmondson C, Wirth B, Sanford JR, Chen B, Splicing factor TRA2B is required for neural progenitor survival. J Comp Neurol. 2014 Feb 1;522(2):372-92
1J:168833 Rosenbaum JN, Duggan A, Garcia-Anoveros J, Insm1 promotes the transition of olfactory progenitors from apical and proliferative to basal, terminally dividing and neuronogenic. Neural Dev. 2011;6:6
1J:313340 Rosin JM, Kurrasch DM, Cobb J, Shox2 is required for the proper development of the facial motor nucleus and the establishment of the facial nerves. BMC Neurosci. 2015 Jul 9;16:39
1*J:219823 Rosin JM, McAllister BB, Dyck RH, Percival CJ, Kurrasch DM, Cobb J, Mice lacking the transcription factor SHOX2 display impaired cerebellar development and deficits in motor coordination. Dev Biol. 2015 Mar 1;399(1):54-67
1J:137277 Ross A, Munger S, Capel B, Bmp7 regulates germ cell proliferation in mouse fetal gonads. Sex Dev. 2007;1(2):127-37
1*J:306391 Roth DM, Baddam P, Lin H, Vidal-Garcia M, Aponte JD, De Souza ST, Godziuk D, Watson AES, Footz T, Schachter NF, Egan SE, Hallgrimsson B, Graf D, Voronova A, The Chromatin Regulator Ankrd11 Controls Palate and Cranial Bone Development. Front Cell Dev Biol. 2021;9:645386
1*J:59317 Roth KA, Kuan C, Haydar TF, D'Sa-Eipper C, Shindler KS, Zheng TS, Kuida K, Flavell RA, Rakic P, Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death. Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):466-71
1J:274433 Roy A, Francius C, Rousso DL, Seuntjens E, Debruyn J, Luxenhofer G, Huber AB, Huylebroeck D, Novitch BG, Clotman F, Onecut transcription factors act upstream of Isl1 to regulate spinal motoneuron diversification. Development. 2012 Sep;139(17):3109-19
1J:333796 Ruiz-Reig N, Chehade G, Hakanen J, Aittaleb M, Wierda K, De Wit J, Nguyen L, Gailly P, Tissir F, KIF2A deficiency causes early-onset neurodegeneration. Proc Natl Acad Sci U S A. 2022 Nov 16;119(46):e2209714119
1J:341708 Saha S, Jungas TT, Ohayon D, Audouard C, Ye T, Fawal MA, Davy A, Dihydrofolate reductase activity controls neurogenic transitions in the developing neocortex. Development. 2023 Oct 15;150(20):dev201696
1J:154951 Sahara S, O'Leary DD, Fgf10 regulates transition period of cortical stem cell differentiation to radial glia controlling generation of neurons and basal progenitors. Neuron. 2009 Jul 16;63(1):48-62
1*J:148533 Saito K, Dubreuil V, Arai Y, Wilsch-Brauninger M, Schwudke D, Saher G, Miyata T, Breier G, Thiele C, Shevchenko A, Nave KA, Huttner WB, Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis. Proc Natl Acad Sci U S A. 2009 May 19;106(20):8350-5
1J:323013 Sakai D, Sugawara T, Kurokawa T, Murakami Y, Tomosugi M, Masuta H, Sakata-Haga H, Hatta T, Shoji H, Hif1alpha-dependent hypoxia signaling contributes to the survival of deep-layer neurons and cortex formation in a mouse model. Mol Brain. 2022 Mar 31;15(1):28
1J:320198 Sakai SS, Hasegawa A, Ishimura R, Tamura N, Kageyama S, Komatsu-Hirota S, Abe M, Ling Y, Okuda S, Funayama M, Kikkawa M, Miura Y, Sakimura K, Narita I, Waguri S, Shimizu R, Komatsu M, Loss of Atg2b and Gskip Impairs the Maintenance of the Hematopoietic Stem Cell Pool Size. Mol Cell Biol. 2022 Jan 20;42(1):e0002421
1J:286655 Sakamoto S, Tateya T, Omori K, Kageyama R, Id genes are required for morphogenesis and cellular patterning in the developing mammalian cochlea. Dev Biol. 2020 Apr 15;460(2):164-175
1J:187697 Sasaki M, Knobbe CB, Itsumi M, Elia AJ, Harris IS, Chio II, Cairns RA, McCracken S, Wakeham A, Haight J, Ten AY, Snow B, Ueda T, Inoue S, Yamamoto K, Ko M, Rao A, Yen KE, Su SM, Mak TW, D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function. Genes Dev. 2012 Sep 15;26(18):2038-49
1J:193342 Schmidt-Strassburger U, Schips TG, Maier HJ, Kloiber K, Mannella F, Braunstein KE, Holzmann K, Ushmorov A, Liebau S, Boeckers TM, Wirth T, Expression of constitutively active FoxO3 in murine forebrain leads to a loss of neural progenitors. FASEB J. 2012 Dec;26(12):4990-5001
1J:171905 Scott A, Hasegawa H, Sakurai K, Yaron A, Cobb J, Wang F, Transcription factor short stature homeobox 2 is required for proper development of tropomyosin-related kinase B-expressing mechanosensory neurons. J Neurosci. 2011 May 4;31(18):6741-9
1J:268910 Segura-Bayona S, Knobel PA, Gonzalez-Buron H, Youssef SA, Pena-Blanco A, Coyaud E, Lopez-Rovira T, Rein K, Palenzuela L, Colombelli J, Forrow S, Raught B, Groth A, de Bruin A, Stracker TH, Differential requirements for Tousled-like kinases 1 and 2 in mammalian development. Cell Death Differ. 2017 Nov;24(11):1872-1885
1J:119477 Shaw AT, Meissner A, Dowdle JA, Crowley D, Magendantz M, Ouyang C, Parisi T, Rajagopal J, Blank LJ, Bronson RT, Stone JR, Tuveson DA, Jaenisch R, Jacks T, Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis. Genes Dev. 2007 Mar 15;21(6):694-707
1J:289625 Shawer H, Aiyelaagbe E, Clowes C, Lean SC, Lu Y, Kadler KE, Kerby A, Dilworth MR, Hentges KE, Heazell AEP, A missense mutation of ErbB2 produces a novel mouse model of stillbirth associated with a cardiac abnormality but lacking abnormalities of placental structure. PLoS One. 2020;15(6):e0233007
1J:291483 Sheehan CJ, McMahon JJ, Serdar LD, Silver DL, Dosage-dependent requirements of Magoh for cortical interneuron generation and survival. Development. 2020 Jan 13;147(1):dev182295
1J:243695 Sherf O, Nashelsky Zolotov L, Liser K, Tilleman H, Jovanovic VM, Zega K, Jukic MM, Brodski C, Otx2 Requires Lmx1b to Control the Development of Mesodiencephalic Dopaminergic Neurons. PLoS One. 2015;10(10):e0139697
1*J:276703 Shi J, Gao Q, Cao Y, Fu J, Dennd1a, a susceptibility gene for polycystic ovary syndrome, is essential for mouse embryogenesis. Dev Dyn. 2019 May;248(5):351-362
1J:168563 Shi Y, Liu JP, Gdf11 facilitates temporal progression of neurogenesis in the developing spinal cord. J Neurosci. 2011 Jan 19;31(3):883-93
1J:170671 Shibata M, Nakao H, Kiyonari H, Abe T, Aizawa S, MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors. J Neurosci. 2011 Mar 2;31(9):3407-22
1J:294895 Shpargel KB, Mangini CL, Xie G, Ge K, Magnuson T, The KMT2D Kabuki syndrome histone methylase controls neural crest cell differentiation and facial morphology. Development. 2020 Jul 17;147(21):dev187997
1J:159625 Silver DL, Watkins-Chow DE, Schreck KC, Pierfelice TJ, Larson DM, Burnetti AJ, Liaw HJ, Myung K, Walsh CA, Gaiano N, Pavan WJ, The exon junction complex component Magoh controls brain size by regulating neural stem cell division. Nat Neurosci. 2010 May;13(5):551-8
1J:275391 Simmons AJ, Park R, Sterling NA, Jang MH, van Deursen JMA, Yen TJ, Cho SH, Kim S, Nearly complete deletion of BubR1 causes microcephaly through shortened mitosis and massive cell death. Hum Mol Genet. 2019 Jun 1;28(11):1822-1836
1J:185693 Smith CL, Baek ST, Sung CY, Tallquist MD, Epicardial-derived cell epithelial-to-mesenchymal transition and fate specification require PDGF receptor signaling. Circ Res. 2011 Jun 10;108(12):e15-26
1J:223201 Song R, Preston G, Ichihara A, Yosypiv IV, Deletion of the prorenin receptor from the ureteric bud causes renal hypodysplasia. PLoS One. 2013;8(5):e63835
1J:204680 Sugiyama Y, Shelley EJ, Wen L, Stump RJ, Shimono A, Lovicu FJ, McAvoy JW, Sfrp1 and Sfrp2 are not involved in Wnt/beta-catenin signal silencing during lens induction but are required for maintenance of Wnt/beta-catenin signaling in lens epithelial cells. Dev Biol. 2013 Dec 15;384(2):181-93
1J:235118 Sun C, Yu D, Ye W, Liu C, Gu S, Sinsheimer NR, Song Z, Li X, Chen C, Song Y, Wang S, Schrader L, Chen Y, The short stature homeobox 2 (Shox2)-bone morphogenetic protein (BMP) pathway regulates dorsal mesenchymal protrusion development and its temporary function as a pacemaker during cardiogenesis. J Biol Chem. 2015 Jan 23;290(4):2007-23
1*J:235626 Sun J, Ting MC, Ishii M, Maxson R, Msx1 and Msx2 function together in the regulation of primordial germ cell migration in the mouse. Dev Biol. 2016 Sep 1;417(1):11-24
1J:134487 Suzuki A, Sekiya S, Buscher D, Izpisua Belmonte JC, Taniguchi H, Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19ARF expression. Development. 2008 May;135(9):1589-95
1J:184006 Tang K, Rubenstein JL, Tsai SY, Tsai MJ, COUP-TFII controls amygdala patterning by regulating neuropilin expression. Development. 2012 May;139(9):1630-9
1J:101924 Tang LS, Wlodarczyk BJ, Santillano DR, Miranda RC, Finnell RH, Developmental consequences of abnormal folate transport during murine heart morphogenesis. Birth Defects Res A Clin Mol Teratol. 2004 Jul;70(7):449-58
1J:149534 Tang M, Miyamoto Y, Huang EJ, Multiple roles of {beta}-catenin in controlling the neurogenic niche for midbrain dopamine neurons. Development. 2009 Jun;136(12):2027-38
1J:161771 Tang M, Villaescusa JC, Luo SX, Guitarte C, Lei S, Miyamoto Y, Taketo MM, Arenas E, Huang EJ, Interactions of Wnt/beta-catenin signaling and sonic hedgehog regulate the neurogenesis of ventral midbrain dopamine neurons. J Neurosci. 2010 Jul 7;30(27):9280-91
1J:278287 Tang T, Zhang Y, Wang Y, Cai Z, Lu Z, Li L, Huang R, Hagelkruys A, Matthias P, Zhang H, Seiser C, Xie Y, HDAC1 and HDAC2 Regulate Intermediate Progenitor Positioning to Safeguard Neocortical Development. Neuron. 2019 Mar 20;101(6):1117-1133.e5
1J:103924 Tarchini B, Huynh TH, Cox GA, Duboule D, HoxD cluster scanning deletions identify multiple defects leading to paralysis in the mouse mutant Ironside. Genes Dev. 2005 Dec 1;19(23):2862-76
1J:229385 Teshima TH, Wells KL, Lourenco SV, Tucker AS, Apoptosis in Early Salivary Gland Duct Morphogenesis and Lumen Formation. J Dent Res. 2016 Mar;95(3):277-83
1J:237527 Thein T, de Melo J, Zibetti C, Clark BS, Juarez F, Blackshaw S, Control of lens development by Lhx2-regulated neuroretinal FGFs. Development. 2016 Nov 01;143(21):3994-4002
1J:197487 Tiberi L, van den Ameele J, Dimidschstein J, Piccirilli J, Gall D, Herpoel A, Bilheu A, Bonnefont J, Iacovino M, Kyba M, Bouschet T, Vanderhaeghen P, BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets. Nat Neurosci. 2012 Dec;15(12):1627-35
1J:128012 Todorovic V, Frendewey D, Gutstein DE, Chen Y, Freyer L, Finnegan E, Liu F, Murphy A, Valenzuela D, Yancopoulos G, Rifkin DB, Long form of latent TGF-beta binding protein 1 (Ltbp1L) is essential for cardiac outflow tract septation and remodeling. Development. 2007 Oct;134(20):3723-32
1J:343099 Tonosaki M, Fujimori A, Yaoi T, Itoh K, Loss of Aspm causes increased apoptosis of developing neural cells during mouse cerebral corticogenesis. PLoS One. 2023;18(11):e0294893
1*J:237223 Torii H, Yoshida A, Katsuno T, Nakagawa T, Ito J, Omori K, Kinoshita M, Yamamoto N, Septin7 regulates inner ear formation at an early developmental stage. Dev Biol. 2016 Nov 15;419(2):217-228
1J:264124 Tsushima H, Tang YJ, Puviindran V, Hsu SC, Nadesan P, Yu C, Zhang H, Mirando AJ, Hilton MJ, Alman BA, Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis. Development. 2018 Jul 9;145(13):dev162396
1J:307951 Turnis ME, Kaminska E, Smith KH, Kartchner BJ, Vogel P, Laxton JD, Ashmun RA, Ney PA, Opferman JT, Requirement for antiapoptotic MCL-1 during early erythropoiesis. Blood. 2021 Apr 8;137(14):1945-1958
1J:160285 Uchiyama Y, Sakaguchi M, Terabayashi T, Inenaga T, Inoue S, Kobayashi C, Oshima N, Kiyonari H, Nakagata N, Sato Y, Sekiguchi K, Miki H, Araki E, Fujimura S, Tanaka SS, Nishinakamura R, Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9240-5
1*J:314103 Ulmke PA, Sakib MS, Ditte P, Sokpor G, Kerimoglu C, Pham L, Xie Y, Mao X, Rosenbusch J, Teichmann U, Nguyen HP, Fischer A, Eichele G, Staiger JF, Tuoc T, Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex. Stem Cell Reports. 2021 Apr 13;16(4):968-984
1*J:302538 Ulmke PA, Xie Y, Sokpor G, Pham L, Shomroni O, Berulava T, Rosenbusch J, Basu U, Fischer A, Nguyen HP, Staiger JF, Tuoc T, Post-transcriptional regulation by the exosome complex is required for cell survival and forebrain development via repression of P53 signaling. Development. 2021 Feb 8;148(3):dev188276
1J:178971 Valenta T, Gay M, Steiner S, Draganova K, Zemke M, Hoffmans R, Cinelli P, Aguet M, Sommer L, Basler K, Probing transcription-specific outputs of beta-catenin in vivo. Genes Dev. 2011 Dec 15;25(24):2631-43
1J:261301 Van den Ackerveken P, Mounier A, Huyghe A, Sacheli R, Vanlerberghe PB, Volvert ML, Delacroix L, Nguyen L, Malgrange B, The miR-183/ItgA3 axis is a key regulator of prosensory area during early inner ear development. Cell Death Differ. 2017 Dec;24(12):2054-2065
1J:304564 Venkataramanappa S, Schutz D, Saaber F, Kumar PA, Abe P, Schulz S, Stumm R, The microcephaly gene Donson is essential for progenitors of cortical glutamatergic and GABAergic neurons. PLoS Genet. 2021 Mar;17(3):e1009441
1*J:277247 Vetrivel S, Tiso N, Kugler A, Irmler M, Horsch M, Beckers J, Hladik D, Giesert F, Gailus-Durner V, Fuchs H, Sabrautzki S, Adler T, Treise I, Busch DH, Aguilar-Pimentel A, Ollert M, Gotz A, Amarie OV, Stoeger T, Schulz H, Becker L, Klopstock T, Schrewe A, Spielmann N, Bekeredjian R, Garrett L, Holter SM, Zimprich A, Wurst W, Mayer-Kuckuk P, Hans W, Rozman J, Klingenspor M, Neff F, da Silva-Buttkus P, Calzada-Wack J, Racz I, Zimmer A, Rathkolb B, Wolf E, Prehn C, Adamski J, Ostereicher M, Miller G, Steinkamp R, Lengger C, Maier H, Stoeger C, Leuchtenberger S, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Hrabe de Angelis M, Graw J, Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia. Exp Eye Res. 2019 Apr 13;
1J:193303 Vidaki M, Tivodar S, Doulgeraki K, Tybulewicz V, Kessaris N, Pachnis V, Karagogeos D, Rac1-dependent cell cycle exit of MGE precursors and GABAergic interneuron migration to the cortex. Cereb Cortex. 2012 Mar;22(3):680-92
1J:311908 Vogel JK, Weider M, Engler LA, Hillgartner S, Schmitt C, Hermans-Borgmeyer I, Wegner M, Sox9 overexpression exerts multiple stage-dependent effects on mouse spinal cord development. Glia. 2020 May;68(5):932-946
1J:199419 Walker KA, Sims-Lucas S, Di Giovanni VE, Schaefer C, Sunseri WM, Novitskaya T, de Caestecker MP, Chen F, Bates CM, Deletion of fibroblast growth factor receptor 2 from the peri-wolffian duct stroma leads to ureteric induction abnormalities and vesicoureteral reflux. PLoS One. 2013;8(2):e56062
1J:123221 Wang CZ, Shi M, Yang LL, Yang RQ, Luo ZG, Jacquin MF, Chen ZF, Ding YQ, Development of the mesencephalic trigeminal nucleus requires a paired homeodomain transcription factor, Drg11. Mol Cell Neurosci. 2007 Jun;35(2):368-76
1*J:297051 Wang S, Roy JP, Tomlinson AJ, Wang EB, Tsai YH, Cameron L, Underwood J, Spence JR, Walton KD, Stacker SA, Gumucio DL, Lechler T, RYK-mediated filopodial pathfinding facilitates midgut elongation. Development. 2020 Oct 27;147(20):dev195388
1*J:198233 Wang Y, Lin L, Lai H, Parada LF, Lei L, Transcription factor Sox11 is essential for both embryonic and adult neurogenesis. Dev Dyn. 2013 Jun;242(6):638-53
1J:166929 Wang Y, Martin JF, Bai CB, Direct and indirect requirements of Shh/Gli signaling in early pituitary development. Dev Biol. 2010 Dec 15;348(2):199-209
1J:323216 Wang YB, Song NN, Zhang L, Ma P, Chen JY, Huang Y, Hu L, Mao B, Ding YQ, Rnf220 is Implicated in the Dorsoventral Patterning of the Hindbrain Neural Tube in Mice. Front Cell Dev Biol. 2022;10:831365
1J:195156 Watkins-Chow DE, Cooke J, Pidsley R, Edwards A, Slotkin R, Leeds KE, Mullen R, Baxter LL, Campbell TG, Salzer MC, Biondini L, Gibney G, Phan Dinh Tuy F, Chelly J, Morris HD, Riegler J, Lythgoe MF, Arkell RM, Loreni F, Flint J, Pavan WJ, Keays DA, Mutation of the diamond-blackfan anemia gene Rps7 in mouse results in morphological and neuroanatomical phenotypes. PLoS Genet. 2013 Jan;9(1):e1003094
1J:206929 Watson LA, Wang X, Elbert A, Kernohan KD, Galjart N, Berube NG, Dual Effect of CTCF Loss on Neuroprogenitor Differentiation and Survival. J Neurosci. 2014 Feb 19;34(8):2860-70
1J:329947 Wei W, Tang X, Jiang N, Ni C, He H, Sun S, Yu M, Yu C, Qiu M, Yan D, Zhou Z, Song Y, Liu H, Zhao B, Lin X, Chromatin remodeler Znhit1 controls bone morphogenetic protein signaling in embryonic lung tissue branching. J Biol Chem. 2022 Sep 14;298(10):102490
1J:305176 Wei Y, Han X, Zhao C, PDK1 regulates the survival of the developing cortical interneurons. Mol Brain. 2020 May 4;13(1):65
1J:264402 Welsh IC, Hart J, Brown JM, Hansen K, Rocha Marques M, Aho RJ, Grishina I, Hurtado R, Herzlinger D, Ferretti E, Garcia-Garcia MJ, Selleri L, Pbx loss in cranial neural crest, unlike in epithelium, results in cleft palate only and a broader midface. J Anat. 2018 Aug;233(2):222-242
1J:225359 Wende CZ, Zoubaa S, Blak A, Echevarria D, Martinez S, Guillemot F, Wurst W, Guimera J, Hairy/Enhancer-of-Split MEGANE and Proneural MASH1 Factors Cooperate Synergistically in Midbrain GABAergic Neurogenesis. PLoS One. 2015;10(5):e0127681
1*J:311932 White AK, Baumgartner M, Lee MF, Drake KD, Aquino GS, Kanadia RN, Trp53 ablation fails to prevent microcephaly in mouse pallium with impaired minor intron splicing. Development. 2021 Oct 15;148(20):dev199591
1J:196616 Willaredt MA, Gorgas K, Gardner HA, Tucker KL, Multiple essential roles for primary cilia in heart development. Cilia. 2012;1(1):23
1J:111725 Williams ME, Lu X, McKenna WL, Washington R, Boyette A, Strickland P, Dillon A, Kaprielian Z, Tessier-Lavigne M, Hinck L, UNC5A promotes neuronal apoptosis during spinal cord development independent of netrin-1. Nat Neurosci. 2006 Aug;9(8):996-8
1J:229488 Wiszniak S, Harvey N, Schwarz Q, Cell autonomous roles of Nedd4 in craniofacial bone formation. Dev Biol. 2016 Feb 1;410(1):98-107
1J:339438 Wong W, Estep JA, Treptow AM, Rajabli N, Jahncke JN, Ubina T, Wright KM, Riccomagno MM, An adhesion signaling axis involving Dystroglycan, beta1-Integrin, and Cas adaptor proteins regulates the establishment of the cortical glial scaffold. PLoS Biol. 2023 Aug;21(8):e3002212
1J:326029 Wu Y, Yang D, Chen GY, Targeted disruption of Gdi2 causes early embryonic lethality. Placenta. 2022 May 13;126:17-25
1*J:263975 Xie Z, Hur SK, Zhao L, Abrams CS, Bankaitis VA, A Golgi Lipid Signaling Pathway Controls Apical Golgi Distribution and Cell Polarity during Neurogenesis. Dev Cell. 2018 Mar 26;44(6):725-740.e4
1J:217617 Xiong Y, Yang P, Proia RL, Hla T, Erythrocyte-derived sphingosine 1-phosphate is essential for vascular development. J Clin Invest. 2014 Nov;124(11):4823-8
1J:128008 Xu H, Chen L, Baldini A, In vivo genetic ablation of the periotic mesoderm affects cell proliferation survival and differentiation in the cochlea. Dev Biol. 2007 Oct 15;310(2):329-40
1J:345074 Yamanaka T, Kurosawa M, Yoshida A, Shimogori T, Hiyama A, Maity SN, Hattori N, Matsui H, Nukina N, The transcription factor NF-YA is crucial for neural progenitor maintenance during brain development. J Biol Chem. 2024 Jan 8;300(2):105629
1J:176226 Yan CH, Levesque M, Claxton S, Johnson RL, Ang SL, Lmx1a and lmx1b function cooperatively to regulate proliferation, specification, and differentiation of midbrain dopaminergic progenitors. J Neurosci. 2011 Aug 31;31(35):12413-25
1J:298597 Yan S, Thienthanasit R, Chen D, Engelen E, Bruhl J, Crossman DK, Kesterson R, Wang Q, Bouazoune K, Jiao K, CHD7 regulates cardiovascular development through ATP-dependent and -independent activities. Proc Natl Acad Sci U S A. 2020 Nov 17;117(46):28847-28858
1J:107396 Yang L, Cai CL, Lin L, Qyang Y, Chung C, Monteiro RM, Mummery CL, Fishman GI, Cogen A, Evans S, Isl1Cre reveals a common Bmp pathway in heart and limb development. Development. 2006 Apr;133(8):1575-85
1J:242896 Yao C, Carraro G, Konda B, Guan X, Mizuno T, Chiba N, Kostelny M, Kurkciyan A, David G, McQualter JL, Stripp BR, Sin3a regulates epithelial progenitor cell fate during lung development. Development. 2017 Jul 15;144(14):2618-2628
1J:210623 Yeh ML, Gonda Y, Mommersteeg MT, Barber M, Ypsilanti AR, Hanashima C, Parnavelas JG, Andrews WD, Robo1 modulates proliferation and neurogenesis in the developing neocortex. J Neurosci. 2014 Apr 16;34(16):5717-31
1J:243989 Yeung J, Goldowitz D, Wls expression in the rhombic lip orchestrates the embryonic development of the mouse cerebellum. Neuroscience. 2017 Jun 23;354:30-42
1J:290855 Yu W, Sun Z, Sweat Y, Sweat M, Venugopalan SR, Eliason S, Cao H, Paine ML, Amendt BA, Pitx2-Sox2-Lef1 interactions specify progenitor oral/dental epithelial cell signaling centers. Development. 2020 Jun 4;147(11):dev186023
1J:153550 Yu W, Wang Y, McDonnell K, Stephen D, Bai CB, Patterning of ventral telencephalon requires positive function of Gli transcription factors. Dev Biol. 2009 Oct 1;334(1):264-75
1J:274106 Zaqout S, Bessa P, Kramer N, Stoltenburg-Didinger G, Kaindl AM, CDK5RAP2 Is Required to Maintain the Germ Cell Pool during Embryonic Development. Stem Cell Reports. 2017 Feb 14;8(2):198-204
1J:251744 Zega K, Jovanovic VM, Vitic Z, Niedzielska M, Knaapi L, Jukic MM, Partanen J, Friedel RF, Lang R, Brodski C, Dusp16 Deficiency Causes Congenital Obstructive Hydrocephalus and Brain Overgrowth by Expansion of the Neural Progenitor Pool. Front Mol Neurosci. 2017;10:372
1J:243678 Zemke M, Draganova K, Klug A, Scholer A, Zurkirchen L, Gay MH, Cheng P, Koseki H, Valenta T, Schubeler D, Basler K, Sommer L, Loss of Ezh2 promotes a midbrain-to-forebrain identity switch by direct gene derepression and Wnt-dependent regulation. BMC Biol. 2015 Nov 30;13:103
1J:239540 Zhang G, Xie Y, Zhou Y, Xiang C, Chen L, Zhang C, Hou X, Chen J, Zong H, Liu G, p53 pathway is involved in cell competition during mouse embryogenesis. Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):498-503
1J:117465 Zhang J, Pho V, Bonasera SJ, Holtzman J, Tang AT, Hellmuth J, Tang S, Janak PH, Tecott LH, Huang EJ, Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons. Nat Neurosci. 2007 Jan;10(1):77-86
1J:314661 Zhang Q, Huang R, Ye Y, Guo X, Lu J, Zhu F, Gong X, Zhang Q, Yan J, Luo L, Zhuang S, Chen Y, Zhao X, Evans SM, Jiang C, Liang X, Sun Y, Temporal requirements for ISL1 in sympathetic neuron proliferation, differentiation, and diversification. Cell Death Dis. 2018 Feb 14;9(2):247
1J:328995 Zhang SF, Dai SK, Du HZ, Wang H, Li XG, Tang Y, Liu CM, The epigenetic state of EED-Gli3-Gli1 regulatory axis controls embryonic cortical neurogenesis. Stem Cell Reports. 2022 Sep 13;17(9):2064-2080
1*J:281166 Zhang X, Zhang H, Xu C, Li X, Li M, Wu X, Pu W, Zhou B, Wang H, Li D, Ding Q, Ying H, Wang H, Zhang H, Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis. Nat Commun. 2019 Sep 13;10(1):4158
1*J:324720 Zhao Q, Yan S, Lu J, Parker DJ, Wu H, Sun Q, Crossman DK, Liu S, Wang Q, Sesaki H, Mitra K, Liu K, Jiao K, Drp1 regulates transcription of ribosomal protein genes in embryonic hearts. J Cell Sci. 2022 Feb 15;135(4):jcs258956
1J:275567 Zurkirchen L, Varum S, Giger S, Klug A, Hausel J, Bossart R, Zemke M, Cantu C, Atak ZK, Zamboni N, Basler K, Sommer L, Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner. Nat Commun. 2019 May 16;10(1):2192

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
04/23/2024
MGI 6.23
The Jackson Laboratory